High purity Vinpocetine with best quality

Product Name:

Vinpocetine

Synonyms:

3A,16A-APOVINCAMINIC ACID ETHYL ESTER;(3A,16A)-EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER;CAVINTON;ETHYL APOVINCAMIN-22-OATE;EBURNAMENINE;EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER;RGH-4405;VINPOCETIN

CAS:

42971-09-5

MF:

C22H26N2O2

MW:

350.45

Product Categories:

Active Pharmaceutical Ingredients;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cyclic Nucleotide related;Chiral Reagents;Heterocycles;ACTONEL;Cardiovascular APIs

Mol File:

42971-09-5.mol

Chemical Properties

melting point 

147-153 °C dec.

storage temp. 

Store at RT

solubility 

DMSO: 5 mg/mL

Stability

Photosensitive

Usage And Synthesis

Pharmacokinetics

Vinpocetine is of high fat-solubility, easy to be absorbed by the organization, and widely distributed. It can through the blood brain barrier, mainly metabolism to Vinpocetine in the liver, and be excreted by the kidney.

Side Effects

Nervous system: head heavy, dizziness, occasional tiredness and side limb numbness, etc. 
Digestive system: nausea, vomiting, loss of appetite, abdominal pain, diarrhea, etc. 
Circulatory system: facial blushing, dizziness and other symptoms. 
Blood system: white blood cells reduction.
Liver reaction: AST, ALT elevations, rare elevation of alkaline phosphatase. 
Kidney reaction: blood urea nitrogen increasing. 
Sometimes allergic reactions like skin rash, urticarial and pruritus may appear, then drug should be discontinued. Occasional mild lowering blood pressure, tachycardia, etc.

Usage

Cerebrovascular drug. A alkaloid extracted from apocynaceae plant, Vincamine derivatives. Selectively inhibit vascular smooth muscle calcium dependency phosphodiesterase, and increase the content of cGMP, expanse cerebral vascular, which in turn increase cerebral blood flow, improve cerebral circulation, but has little effects on the cardiovascular and blood pressure. Effectively, good tolerance, less adverse reaction. Used for dizziness, headache, memory disorders, movement disorder, aphasia, hypertensive encephalopathy, etc.. Can also be used in brain blood circulation obstacle caused by mental or neurological symptoms.
This information is edited by ChemicalBook Xiao Nan.

A calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) inhibitor

A derivative of Vincamine with vasodilating activity. Vasodilator (cerebral).

calcium regulator

Gleevec metabolite, tyrosine kinase inhibitor

Biological Activity

Phosphodiesterase inhibitor, selective for PDE1 (IC 50 = 21 μ M). Also blocks voltage-gated Na + channels.