High purity Fludarabine with good quality

Product Name:

Fludarabine

Synonyms:

2-Fluoroadeninearabinoside;9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin;9-beta-d-arabinofuranosyl-2-fluoro-adenin;f-ara-a;6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE;9-bata-d-arabinofuranosyl-2-fluoroadenine;9-BETA-D-ARABINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE;9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE

CAS:

21679-14-1

MF:

C10H12FN5O4

MW:

285.23

Product Categories:

Intermediates & Fine Chemicals;Pharmaceuticals;API;F-ara-A, NSC 118218;Anti-cancer&immunity;Inhibitors

Mol File:

21679-14-1.mol

Chemical Properties

melting point 

265-268°C

boiling point 

747.3 °C at 760 mmHg

density 

2.17 g/cm3

flashing point 

405.8 °C

vapor pressure 

1.86E-23 mmHg at 25°C

storage temp. 

2-8°C

solubility 

DMF: 20 mg/mL, clear, faintly yellow

Usage And Synthesis

Chemical Properties

White Solid

Usage

Used as an antineoplastic

A STAT-1 activation inhibitor and a DNA synthesis inhibitor.

phosphate as antineoplastic;inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase

Irreversible muscarinic agonist

DNA synthesis and methylation inhibitor;A cell permeable agent that interferes with DNA synthesis and repair; also inhibits RNA transcription

Biological Activity

Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 μ M in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Displays anticancer activity against hematological malignancies in vivo.