High purity Decitabine with best quality

Product Name:

5-Aza-2'-deoxycytidine

Synonyms:

4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-on;4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-one;5-azadeoxycytidine;5-triazin-2(1h)-one,4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-3;2'-DEOXY-5-AZACYTIDINE;4-AMINO-1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-1,3,5-TRIAZIN-2(1H)-ONE;5-AZA-2'-DEOXYCYTIDINE;5-AZA-CDR

CAS:

2353-33-5

MF:

C8H12N4O4

MW:

228.21

Product Categories:

API;Bases & Related Reagents;Nucleotides;analog of cytosine;Intermediates & Fine Chemicals;Pharmaceuticals;Epigenetics;Inhibitor;Deoxycytidine;Anti-cancer&immunity;Inhibitors

Mol File:

2353-33-5.mol

Chemical Properties

melting point 

~200 °C (dec.)

boiling point 

485.8 °C at 760 mmHg

density 

1.9 g/cm3

flashing point 

247.6 °C

vapor pressure 

1.78E-11 mmHg at 25 °C

storage temp. 

−20°C

solubility 

acetic acid/water (1:1): 50 mg/mL, easily absorb moisture,hardly soluble in water,slightly dissolving in methanol,soluble in dimethyl sulfoxide,practically soluble in acetone and methylene chloride

stability

Stable. May be light or air sensitive. Incompatible with strong oxidizing agents.

Usage And Synthesis

Chemical Properties

white crystalline powder

Usage

Used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines.

Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively

General Description

Used as a drug.

Air & Water Reactions

Probably light and air sensitive. Water soluble. Decomposes in aqueous solution at a rate that depends on pH: at pH 7 the drug is more stable than at pH 9, but is less stable than at pH 6. At pH 7 and 99°F, approximately 7% conversion occurs in 1 hour .

Fire Hazard

Flash point data for 5-Aza-2'-deoxycytidine are not available. 5-Aza-2'-deoxycytidine is probably combustible.

Biological Activity

Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.