High purity Mevastatin with best price and quality

Product Name:

Mevastatin

Synonyms:

ML-236B;,8-beta(2s*,4s*),8a-beta))-;antibioticml236b;butanoicacid,2-methyl-,1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hy;compactin(penicillium);droxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenylester,(1s-(1-alpha(r*),7-beta;ml236blactone;6-DEMETHYLVEVINOLIN

CAS:

73573-88-3

MF:

C23H34O5

MW:

390.51

Product Categories:

Active Pharmaceutical Ingredients;Various Metabolites and Impurities;Metabolites;Pharmaceuticals;HMG-CoA reductase;Intermediates & Fine Chemicals;Metabolites & Impurities;Cardiovascular APIs;Inhibitors

Mol File:

73573-88-3.mol

Chemical Properties

melting point 

151-153 °C

boiling point 

555 °C at 760 mmHg

density 

1.13 g/cm3

flashing point 

186.5 °C

vapor pressuer 

1.25E-14 mmHg at 25 °C

storage temp. 

2-8°C

solubility 

DMSO: 20 mg/mL

Usage And Synthesis

Chemical Properties

Off-White Solid

Usage

A fungal metabolite which is a potent inhibitor of HMG-CoA reductase.

antihyperlipidemic, HMGCoA reductase inhibitor

Mevastatin (compactin) is a diterpene produced by several species of the genera Penicillium and Monascus, first reported in 1976. Mevastatin, the prtotype of the statin class, is a potent competitive inhibitor of HMG-CoA reductase, a regulatory enzyme for cholesterol biosynthesis. Mevastatin has also been shown to induce apoptosis by inhibiting post-translational prenylation of proteins such as Ras, increasing eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho, and inhibiting myoblast fusion. It induces cell cycle arrest in late G1 phase and may induce bone morphogenic protein-2 (BMP-2).

anti-hyperlipoproteinemic, 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor

Mevastatin (compactin) is a diterpene produced by several species of the genera Penicillium and Monascus, first reported in 1976. Mevastatin, the prototype of the statin class, is a potent competitive inhibitor of HMG-CoA reductase, a regulatory enzyme for cholesterol biosynthesis. Mevastatin has also been shown to induce apoptosis by inhibiting post-translational prenylation of proteins such as Ras, increasing eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho, and inhibiting myoblast fusion. It induces cell cycle arrest in late G1 phase and may induce bone morphogenic protein-2 (BMP-2).

Biological Activity

Inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo . Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1.