High purity Pravastatin sodium with best price and quality

Product Name:

Pravastatin sodium

Synonyms:

1-naphthaleneheptanoicacid,1,2,6,7,8,8a-hexahydro-2-methyl-8-(2-methyl-1-oxob;2-alpha,6-alpha,8-beta(r*),8a-alpha))-*;cs-514;epastatinsodium;lipostat;sq31000;utoxy)-beta,delta,6-trihydroxy-,monosodiumsalt,(1s-(1-alpha(beta-s*,delta-s;KOPOSTAT

CAS:

81131-70-6

MF:

C23H36NaO7

MW:

447.52

Product Categories:

Active Pharmaceutical Ingredients;Antihyperlipoproteinemic;Various Metabolites and Impurities;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;HMG-CoA reductase;Inhibitor;PRAVACHOL

Mol File:

81131-70-6.mol

Chemical Properties

melting point 

171.2-173 °C

boiling point 

634.5 °C at 760 mmHg

flashing point 

213.2 °C

vapor pressure 

9.15E-19 mmHg at 25 °C

storage temp. 

2-8°C

solubility 

H2O: 19 mg/mL

Usage And Synthesis

Chemical Properties

White Crystalline Powder

Usage

A competitive inhibitor of HMG-CoA reductase. Bioactive metabolite of Mevastatin

antihyperlipidemic, HMGCoA reductase inhibitor

Pravastatin sodium is the salt of pravastatin, a ring-opened member of the statin family. Pravastatin is produced biosynthetically from compactin (mevastatin) by a number of microorganisms, notably Absidia, Cunninghamella, Syncephalastrum, Nocardia or Streptomyces. Typically, statins like compactin, lovastatin and simvastatin possess a β-hydroxy lactone ring which is a pro-drug for the readily ring-opened dihydroxyacid generally regarded as the active HMG-CoAreductase inhibitor. Importantly, the free carboxylic acid enables pravastatin to be freely water soluble within biological pH ranges.

An HMGCR inhibitor which blocks cholesterol synthesis

Biological Activity

Water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (K i ~ 1 nM) and displays cardioprotective properties.