Potassium oxonate

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Molecular formula C4H2KN3O4 CAS No. 2207-75-2 Identification White or almost white crystalline powder Use and Background TS-1 is an anti…

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Molecular formula C4H2KN3O4 CAS No. 2207-75-2 Identification White or almost white crystalline powder Use and Background TS-1 is an anticancer drug containing three components, tegafur, an oral anticancer drug which is a prodrug of 5-fluorouracil (5-FU), 5-chloro-2,4-dihydroxypyridine (CDHP) and monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate (Oxo) . CDHP inhibits the decomposition of 5-FU, whereby it maintains a high concentration of 5-FU in blood. Oxo inhibits the phosphorylation of 5-FU, whereby it attenuates the toxic effects of 5-FU on the gastrointestinal tract.

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