Mebendazole

Details:

Substance Name Mebendazole Synonyms * Mebendazolum [INN-Latin], * (5-Benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester, * (5-Benzoyl-1H-benzimidazol-2-yl)carbamic acid methyl ester, * (5-Benzoyl-1H-benzoimidazol-2-yl)-carbamic acid methyl ester, * 2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester, * 2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester (8CI), * 5-Benzoyl-2-benzimidazolecarbamic acid methyl ester, * 5-Benzoyl-2-benzimidazolecarbamic acid, methyl ester, * AIDS-007900, * AIDS007900, * Bantenol, * BAS 00341140, * Besantin, * Carbamic acid, (5-benzoyl-1H-benzimidazol-2-yl)-, methyl ester, * Carbamic acid, (5-benzoyl-1H-benzimidazol-2-yl)-, methyl ester (9CI), * Carbamic acid, N-(5-benzoylbenzimidazol-2-yl)-, methyl ester, * CBDivE_010559, * CCRIS 4479, * D00368, * DivK1c_000751, * EINECS 250-635-4, * Equivurm Plus, * HSDB 3232, *KBio1_000751, * KBio2_001778, * KBio2_004346, * KBio2_006914, * KBio3_002398, * KBioGR_000712, * KBioSS_001778, * Lomper, * MBDZ, * Mebendazol [INN-Spanish], * MEBENDAZOLE, * Mebendazole (JAN/USP), * Mebendazole [USAN:BAN:INN:JAN], * Mebenoazole, * Mebenvet, * Mebex, * Mebutar, * MLS000028491, * Methyl 5-benzoyl benzimidazole-2-carbamate, * Methyl 5-benzoyl-2-benzimidazolecarbamate, * Methyl 5-benzoyl-2-benzimidazolylcarbamate, * Methyl N-(5-benzoyl-1H-benzimidazol-2-yl)carbamate, * Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate, * N-(Benzoyl-5, benzimidazolyl)-2, carbamate de methyle [French], * N-2 (5-Benzoyl-benzimidazole) carbamate de methyle [French], * NCGC00016806-01, * NINDS_000751, * Noverme, * NSC 184849, * NSC184849, * Ovitelmin, * Pantelmin, * Prestwick0_000217, * Prestwick1_000217, * Prestwick_310, * R 17, 635, * R 17,635, * R 17635, * SMR000036734, * SPBio_001442, * SPBio_002154, * Spectrum2_001401, * Spectrum3_001439, * Spectrum4_000416, * Spectrum_001298, * Sufil, * Telmin, * TimTec1_000869, * Vermex, * Vermicidin, * Vermirax, * Vermox, * Vermox (TN), * Verpanyl, * Versid, * ZINC00001648, * ZINC00121541, Chemical Name methyl 5-benzoylbenzimidazole-2-carbamate Molecular Formula C16H13N3O3 Molecular Weight 295.29 CAS No. 31431-39-7 Chemical Structure Specification EP/USP/CP Pharmacodynamic Properties Mebendazole is a broad-spectrum anthelmintic, it is strongly bound to the worm’s beta microtubules protein tubulin under very low concentration. It interferes with the carbohydrate metabolism and associated energy production of the parasite, inhibits the polymerization of microtubules, and eventually causes selective disappearance of cytoplasmic microtubules in the tegumental and intestinal cells and the slow immobilization and death of the worms by selectively and irreversibly blocking uptake of glucose and other nutrients in susceptible intestine where helminthes dwell. It is also an uncoupler of the mitochondrial oxidative phosphorylation resulting in inhibition of the mitochondrial fumarate reductase and impairing glucose transferring and ATP-synthesis. It is used to treat infections caused by worms such as whipworm, pinworm, roundworm, and hookworm in humans and animals.. It is also used to treat infections caused by more than one of these worms at the same time. Mebendazole is not effective for hydatid disease. Storage Keep container tightly closed in a cool, well-ventilated area. MSDS Provide as per request after the order or contract is signed. [Disclaimer] (1) All rights reserved. Reproduction in whole or part expressly forbidden without written permission. (2) We make effort to ensure the information presented here is accurate, but does not purport to be all inclusive and shall be used only as a reference. (3) We make no warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes.