Closantel sodium

Details:

Substance Name Closantel Sodium Synonyms * Sodium N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-o-tolyl)-2-hydroxy-3,5-diiodobenzamidate, * EINECS 262-794-7 Chemical Name Sodium N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-o-tolyl)-2-hydroxy-3,5-diiodobenzamidate Molecular Formula C23H15Cl2I2N2NaO4 Molecular Weight 731.080 CAS No. 61438-64-0 Chemical Structure Specification CP(V) / EP Pharmacodynamic Properties Closantel is a broad-spectrum antiparasitic agent used against several species and developmental stages of trematodes, nematodes and arthropods. The anti-trematode activity of closantel is mainly used against liver fluke. The anti-nematode and anti-arthropod activity is especially used against those species which feed on blood or plasma. Closantel is an uncoupler of the mitochondrial oxidative phosphorylation resulting in inhibition of the ATP-synthesis. This induces a dramatic change in the energy metabolism which finally leads to the death of the parasite. The drug is widely used in sheep and cattle and can be used either parenterally (s.c. or i.m.) or orally for both prophylactic and therapeutic purposes and is available as drench, bolus and injectable formulations. Closantel has also been combined with mebendazole and several other benzimidazoles in drench formulations for sheep and with levamisole in a bolus for cattle. Storage Keep container tightly closed in a cool, well-ventilated area. MSDS Please refer to MSDS of Closantel. [Disclaimer] (1) All rights reserved. Reproduction in whole or part expressly forbidden without written permission. (2) We make effort to ensure the information presented here is accurate, but does not purport to be all inclusive and shall be used only as a reference. (3) We make no warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes.