Bizelesin Bizelesin 129655-21-6
Product Name: Bizelesin
Synonyms: Bizelesin;1,3-Bis[2-[[[(8S)-8β-chloromethyl-3,6,7,8-tetrahydro-4-hydroxy-1-methylbenzo[1,2-b:4,3-b']dipyrrol]-6-yl]carbonyl]-1H-indol-5-yl]urea;NSC-615291;U-77779;(8S,8'S)-6,6'-[Carbonylbis(iMino-1H- indole-5,2-diylcarbonyl)]bis[8-(chloroMethyl)-3,6,7,8-tetrahydro-1-Methylbe;N,N'-Bis[2-[[(1S)-1-(chloroMethyl)-1,6-dihydro-5-hydroxy-8-Methylbenzo[1,2-b:4,3-b']dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]urea
CAS: 129655-21-6
MF: C43H36Cl2N8O5
MW: 815.714
EINECS:
Product Categories: Chiral Reagents;Indole Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 129655-21-6.mol
Bizelesin Structure
Bizelesin Chemical Properties
Safety Information
MSDS Information
Bizelesin Usage And Synthesis
Uses As members of the cyclopropylpyrroloindole family, Adozelesin and Bizelesin cause genomic DNA lesions by alkylating DNA. Adozelesin induces single-strand DNA lesions, whereas Bizelesin induces both si ngle-strand lesions and double-strand DNA cross-links. liferation by different pathways (i.e., Adozelesin induced apoptosis, and Bizelesin induced senescence).
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