132-60-5

Details:

CINCHOPHEN Basic information
Product Name: CINCHOPHEN
Synonyms: AKOS AU36-M133;AKOS B000030;2-PHENYLQUINOLINE-4-CARBOXYLIC ACID;2-PHENYLQUINOLEINE-4-CARBOXYLIC ACID;2-PHENYLCINCHONINIC ACID;2-PHENYL-4-QUINOLINECARBOXYLIC ACID;CINCHOPHEN;CINCHOPHENE
CAS: 132-60-5
MF: C16H11NO2
MW: 249.26
EINECS: 205-067-1
Product Categories: API intermediates;Quinolinecarboxylic Acids, etc.;Quinolines;ATOPHAN
Mol File: 132-60-5.mol
CINCHOPHEN Structure
CINCHOPHEN Chemical Properties
Melting point  214-215 °C(lit.)
Boiling point  392.37°C (rough estimate)
density  1.1426 (rough estimate)
refractive index  1.5300 (estimate)
storage temp.  Store below +30°C.
solubility  alcohol: soluble1g in 120ml(lit.)
pka 0.96±0.10(Predicted)
Water Solubility  Insoluble in water
Sensitive  Light Sensitive
Merck  14,2288
BRN  192803
Safety Information
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36/37/39-26
RIDADR  3249
WGK Germany  3
RTECS  GD4025000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29334990
Toxicity LD50 oral in dog: 1250mg/kg
MSDS Information
Provider Language

CINCHOPHEN Usage And Synthesis
Chemical Properties BEIGE POWDER
Uses analgesic, antipyretic, antiinflammatory
Brand name Aglophenyl;Alcophenyl;Artexin;Atophan;Cefeno;Cinchophene;Cinconal;Cincosal;Fenofan;Iriphan;Mylofanol;Mylophanol;Phenoquin;Rhematan;Tervalon;Traubofan;Viophan.
World Health Organization (WHO) Cinchophen, an analgesic and antipyretic, was formerly available in preparations for the treatment of gout. Its use was associated with adverse effects including hepatitis, cirrhosis, skin lesions and angioneurotic oedema. WHO has no information to suggest that preparations containing cinchophen remains commercially available.
Purification Methods It crystallises from EtOH (ca 20mL/g), in several modifications with m 196o and 216o(subliming at 65o). [Beilstein 22 H 103, 22 II 518, 22 II 70, 22 III/IV 1358.]
CINCHOPHEN Preparation Products And Raw materials
Raw materials Acetone-->Sodium formate-->Isatin-->Benzoylformic acid