8,10,12-Heptadecatriene-4,6-diyne-1,14-diol,(8E,10E,12E,14R)- Cicutoxin 505-75-9
Formula: | C17H22O2 |
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Exact Mass: | 258.16200 |
Molecular Weight: | 258.35500 |
PSA: | 40.46000 |
LogP: | 2.59530 |
Cicutoxin is a poisonous polyyne and alcohol found in various plants, such as the highly toxic water hemlock (Cicuta species). It is a natural product structurally related to the oenanthotoxin of hemlock water dropwort.
It causes death by disruption of the central nervous system. It is a potent, noncompetitive gamma-aminobutyric acid (GABA) receptor antagonist. In humans, cicutoxin rapidly produces symptoms of nausea, emesis and abdominal pain, typically within 60 minutes of ingestion. This can lead to tremors, seizures, and death. LD50(mouse; i.p.) ~9mg/kg
Density: | 1.025g/cm3 |
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Melting Point: | 54ºC /(-)-form/; 67ºC /(+-)-form/ |
Boiling Point: | 467.2ºC at 760mmHg |
Flash Point: | 218.3ºC |
Refractive Index: | 1.547 |
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