826-39-1 Mecamylamine hydrochloride

Superiority:

Product Name: Mecamylamine hydrochloride
Synonyms: N,2,3,3-TETRAMETHYLBICYCLO[2.2.1]HEPTAN-2-AMINE HYDROCHLORIDE;inversine;mevasinhydrochloride;n,2,3,3-tetramethyl-2-norbornanaminehydrochloride;n,2,3,3-tetramethyl-2-norbornanaminhydrochloride;n-methyl-dl-isobornylaminehydrochloride;Mecamylamine HCl;MECAMYLAMINE USP
CAS: 826-39-1
MF: C11H22ClN
MW: 203.75
EINECS: 212-555-8
Product Categories: Acetylcholine receptor;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors
Mol File: 826-39-1.mol

Mecamylamine hydrochloride Chemical Properties
Melting point  >240°C (dec.)
storage temp.  Desiccate at RT
solubility  ethanol: 122 mg/mL
form  neat
pka pKa 11.2(H2O,t undefined,I=0.1) (Uncertain)
CAS DataBase Reference 826-39-1(CAS DataBase Reference)
EPA Substance Registry System Bicyclo[2.2.1]heptan-2-amine, N,2,3,3-tetramethyl-, hydrochloride (1:1) (826-39-1)
Safety Information
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  36/37/39
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  RB6900000
HazardClass  6.1
HS Code  2921300000

Chemical Properties White Solid
Uses Antihypertensive;Cholinergic receptor antagonist
Uses Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50s range from 1-7 μM). Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.[Cayman Chemical]
Uses A noncompetitive nicotinic AChR inhibitor.
Uses Nicotinic receptor antagonist; orally active ganglionic blocker. Antihypertensive.
General Description The secondary aminemecamylamine hydrochloride, N,2,3,3-tetramethyl-2-norbornanaminehydrochloride (Inversine), has a powerful ganglionicblocking effect that is almost identical to that ofhexamethonium. It has an advantage over most of the ganglionicblocking agents in being absorbed readily andsmoothly from the GI tract. It is rarely used, however, forthe treatment of moderate-to-severe hypertension becausesevere orthostatic hypotension occurs when the drug blockssympathetic ganglia.