4-Acetoxy-2-azetidinone 28562-53-0

Superiority:

Product Name: 4-Acetoxy-2-azetidinone
Synonyms: 2-Azetidinone, 4-(acetyloxy)-;4-Oxo-2-azetidinyl acetate;4-ACETOXY-2-AZETIDINONE;2-oxoazetidinium 4-acetate;4-OXOAZETIDIN-2-YLACETATE;4-ACETOXY-2-AZETIDINONE(4-AA);acetic acid (2-oxo-1-azetidinyl) ester;4-Acetyloxyazetidin-2-one
CAS: 28562-53-0
MF: C5H7NO3
MW: 129.11
EINECS: 249-083-7
Product Categories: Ring Systems;Carbonyl Compounds;Lactams;Organic Building Blocks
Mol File: 28562-53-0.mol

4-Acetoxy-2-azetidinone Chemical Properties
Melting point  38-40 °C(lit.)
Boiling point  239.15°C (rough estimate)
density  1.3816 (rough estimate)
refractive index  1.4220 (estimate)
Fp  >230 °F
storage temp.  2-8°C
solubility  formic acid: soluble50mg/mL, clear, yellow-orange
pka 13.41±0.40(Predicted)
BRN  1524738
CAS DataBase Reference 28562-53-0(CAS DataBase Reference)
NIST Chemistry Reference 4-Acetoxy-2-azetidinone(28562-53-0)
Safety Information
Hazard Codes  C
Risk Statements  34-43
Safety Statements  26-36/37/39-45
RIDADR  UN 1759 8/PG 2
WGK Germany  3
HazardClass  8
PackingGroup  III

Chemical Properties White crystalline powder
Purification Methods Dissolve it in CHCl3, dry (MgSO4) concentrate at 40o/70mm, or better at room temperature to avoid decomposition. Wash and stir the residual oil with hexane by decantation and discard the wash. Dry the oil at high vacuum when it should solidify, m 34o. It can be distilled at high vacuum, 80-82o/10-3mm, but this results in extensive losses. The purity can be checked by TLC using Merck Silica Gel F254 and eluting with EtOAc. The azetidinone has RF 0.38 (typical impurities have RF 0.67). The spots can be detected by the TDM spray. This is prepared from (A) 2.5g 4,4'-tetramethyldiaminodiphenylmethane (TDM) in 10mL AcOH and diluted with 50mL of H2O, (B) 5g KI in 100mL of H2O and (C) 0.3g ninhydrin in 10mL of AcOH and 90mL of H2O. The spray is prepared by mixing (A) and (B) with 1.5mL of (C) and stored in a brown bottle.