989-51-5 (-)-Epigallocatechin gallate

Superiority:

Product Name: (-)-Epigallocatechin gallate
Synonyms: (-)-epigallocathechin gallate;(-)-Epigallocatechin gallate, 98%, from Camellia sinensis(L.)O.Kuntze;(-)-Epigallocatechin gallate in stock Factory;(2R,3R)-2-(3,4,5-TRIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3,5,7-TRIOL 3-(3,4,5-TRIHYDROXYBENZOATE);3,4-DIHYDRO-5,7-DIHYDROXY-2R-(3,4,5-TRIHYDROXYPHENYL)-2H-1-BENZOPYRAN-3R-YL-3,4,5-TRIHYDROXY-BENZOATE;(-)-CIS-3,3',4',5,5',7-HEXAHYDROXY-FLAVANE-3-GALLATE;(-)-CIS-2-(3,4,5-TRIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3,5,7-TRIOL 3-GALLATE;(-)-CIS-3,4-DIHYDRO-5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-1(2H)-BENZOPYRAN-3-YL GALLATE HYDRATE
CAS: 989-51-5
MF: C22H18O11
MW: 458.37
EINECS: 479-560-7
Product Categories: Pharmaceutical Raw Materials;Catechins & Tannins;All Inhibitors;Antioxidant;Biochemistry;Flavonoids;Standard extract;Natural Plant Extract;Inhibitors;Amyloid beta-peptide and related;Aromatics;Heterocycles;ProteasomeInhibitors;Plant extracts;Herb extract;Inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File: 989-51-5.mol

(-)-Epigallocatechin gallate Chemical Properties
Melting point  222-224°C
alpha  D -185 ±2°(ethanol)
refractive index  -175.5 ° (C=1, EtOH)
storage temp.  2-8°C
solubility  H2O: ≥5mg/mL, clear
Boiling point  909.1±65.0 °C(Predicted)
density  1.90±0.1 g/cm3(Predicted)
form  neat
pKa 7.75±0.25(Predicted)
Water Solubility  Soluble in ethanol, dimethyl formamide, water.
Merck  14,3526
Stability: Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
InChIKey WMBWREPUVVBILR-WIYYLYMNSA-N
CAS DataBase Reference 989-51-5(CAS DataBase Reference)
Safety Information
Safety Statements  24/25
WGK Germany  2
RTECS  KB5200000
F  10-23
HS Code  29339900
Toxicity LD50 oral in mouse: 2170mg/kg

(-)-Epigallocatechin gallate Usage And Synthesis
Chemical Properties solid
Uses telomerase inhibitor
Uses An inhibitor of Bcl-2 and NOS2
Uses A tumor-inhibiting constituent of green tea. Alters the cleavage of amyloid precursor protein, decreasing production of amaloid- and amaloid plaques in mice
Hazard Moderately toxic by ingestion.
Anticancer Research EGCG and EGC are the active polyphenol compounds found in green tea, found toinhibit p-glycoprotein transport activities in Chinese hamster ovary (p-gp+) cells.EGCG facilitates the retraction of MDR phenotype by reducing cellular drug effluxwhen given in combination with vinblastine or doxorubicin. Hesperetin, quercetin,daidzein, silymarin, naringenin, and resveratrol also inhibit the MRP1, MRP4, andMRP5 (Kawasaki et al. 2008). Curcumin increases the cellular accumulation ofanticancer agents like cisplatin, tamoxifen, daunorubicin, vincristine, anddoxorubicin and thereby effectively sensitizes the drug-resistant cancer cells. Areduction in MDR1B expression in L1210/Adr cells (mouse leukemic MDR cells)by curcumin is mediated by PI3K, Akt, and NF-κB pathways. It also inhibits theABCG2 transporter activity. In addition curcumin facilitates the accumulation ofmitoxantrone and doxorubicin in ABCG2-expressing HEK cells and hence reversesMDR