8,8'-DIAPOCAROTENEDIOIC ACID 27876-94-4

Superiority:

Product Name: 8,8'-DIAPOCAROTENEDIOIC ACID
Synonyms: (2Z,4E,6Z,8E,10E,12E,14Z)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioic acid;CROCETIN;CROCETIN, TRANS-;8,8'-DIAPOCAROTENEDIOIC ACID;2,6,11,15-TETRAMETHYLHEXADECA-2,4,6,8,10,12,14-HEPTAENEDOIC ACID;TRANS-CROCETIN;8,8'-diapo-psi,psi-carotenedioic acid;8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid
CAS: 27876-94-4
MF: C20H24O4
MW: 328.4
EINECS: 248-708-0
Product Categories: Carotenoids
Mol File: 27876-94-4.mol

8,8'-DIAPOCAROTENEDIOIC ACID Chemical Properties
Melting point  285°
Boiling point  386.14°C (rough estimate)
density  1.0786 (rough estimate)
FEMA  2998 | SAFFRON (CROCUS SATIVUS L.)
refractive index  1.4434 (estimate)
pka 4.39±0.19(Predicted)
Safety Information
HS Code  29171900

8,8'-DIAPOCAROTENEDIOIC ACID Usage And Synthesis
Chemical Properties Red, rhomboid crystals.Soluble in pyridine and dilute sodium hydroxide; slightly soluble in water and organic solvents. Combustible.
Uses Experimental treatment of arteriosclerosis by increasing oxygen diffusion through arterial walls, thus decreasing buildup of cholesterol.
Definition ChEBI: A 20-carbon dicarboxylic acid which is a diterpenoid and natural carotenoid. Found in the crocus flower, it has been administered as an anti-fatigue dietary supplement.
Anticancer Research It is a natural apocarotenoid dicarboxylic acid obtained from saffron, and saffron isa spice from the flower of the Saffron crocus and present in the dry stigmas of theplant Crocus sativus which can be used as a food colorant. It is reported to be anovel anticancer agent against hepatocellular carcinoma, pancreatic cancer, lungcancer, skin carcinoma, breast cancer, and colorectal cancer. It inhibits the nucleicacid synthesis, enhances antioxidant system, induces apoptosis, hinders growthfactor signaling pathways, and thus affects the growth of cancer cells. It showseffects in the reduction of LPS-induced nitric oxide release; in the reduction ofproduced IL-1β, TNF-α, and intracellular ROS; in the activation of NF-κB; and inthe blockade of LPS