42924-53-8 Nabumetone

Superiority:

Product Name: Nabumetone
Synonyms: 4-[6-(trideuteriomethoxy)-2-naphthalenyl]-2-butanone;NABUMETONE, EP STANDARD;NABUMETONE, MM(CRM STANDARD);NABUMETONE, IMP. F (EP): 6,6'-DIMETHOXY-2,2'-BINAPHTHALENYL MM(CRM STANDARD);NABUMETONE, IMPURITY D(E)-4-(6-METHOXYNAPHTHALEN-2-YL)BUT-3-EN-2-ONE EP STANDARD;NABUMETONE, USP(CRM STANDARD);NABUMETONE, BP STANDARD;NABUMETONE:4-（6-METHOXY-2-NAPHTYLBUTAN-2-ONE
CAS: 42924-53-8
MF: C15H16O2
MW: 228.29
EINECS:
Product Categories: Active Pharmaceutical Ingredients;Anti-Inflammatory;Analgesic;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Aromatics;API;BUTYN
Mol File: 42924-53-8.mol

Nabumetone Chemical Properties
Melting point  80-810C
Boiling point  330.1°C (rough estimate)
density  1.0657 (rough estimate)
refractive index  1.5542 (estimate)
storage temp.  Refrigerator
solubility  Soluble in alcohol or chloroform
form  neat
Water Solubility  6mg/L(22.5 ºC)
CAS DataBase Reference 42924-53-8(CAS DataBase Reference)
NIST Chemistry Reference Nabumetone(42924-53-8)
Safety Information
Hazard Codes  Xn
Risk Statements  22-40
Safety Statements  36/37
WGK Germany  2
RTECS  EL9085000
HS Code  2914500000

Nabumetone Usage And Synthesis
Description Nabumetone is a non-acidic, nonsteroidal antiinflammatory agent formally related to naproxen. Its main circulating metabolite is 6-methoxy-2-naphthylacetic acid (α-nornaproxen). Administered once daily (Tsub>1/2 * 30 hrs), nabumetone is reported to be effective in the treatment of rheumatoid and osteoarthritis.
Chemical Properties White Powder
Originator Beecham (United Kingdom)
Uses Anti-inflamatory. Antibacterial
Uses Anti-inflammatory. Antibacterial.
Uses anesthetic (local)
Definition ChEBI: A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is s own to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.
Indications Nabumetone (Relafen) is approved for rheumatoid arthritis, osteoarthritis, and pain management. Its long half-life allows for once-daily dosing. Although this drug is a weak inhibitor of COX, it is metabolized in the liver to 6-methoxy-2-naphthylacetic acid (6-MNA), a strong COX inhibitor that is chemically similar to naproxen. As with most NSAIDs, GI side effects are most commonly reported. The incidence of gastric ulceration is lower with nabumetone than with many other NSAIDs.This is due to its nature as a prodrug, not to COX-2 selectivity. Lower-bowel complaints, rashes, and CNS disturbances are common adverse effects.