Pivalic acid 75-98-9

Superiority:

Product Name: Pivalic acid
Synonyms: TriMethylacetic acid, 99% 100GR;TriMethylacetic acid, 99% 500GR;PIVALIC ACID FOR SYNTHESIS 100 ML;PIVALIC ACID FOR SYNTHESIS 1 L;PA)Pivalic;Pivalic acid 99%;2.2-DiMethylpr;RARECHEM AL BO 0076
CAS: 75-98-9
MF: C5H10O2
MW: 102.13
EINECS: 200-922-5
Product Categories: Building Blocks;C1 to C5;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;Synthesizing medicine intermediate;Intermediates
Mol File: 75-98-9.mol

Pivalic acid Chemical Properties
Melting point  32-35 °C(lit.)
Boiling point  163-164 °C(lit.)
density  0.889 g/mL at 25 °C(lit.)
vapor density  3.6 (vs air)
vapor pressure  9.75 mm Hg ( 60 °C)
refractive index  1.393
Fp  147 °F
storage temp.  2-8°C
solubility  25g/l
form  Powder, Crystals and/or Chunks
pka 5.03(at 25℃)
Specific Gravity 1.121
color  Yellow to orange to tan
explosive limit 1.6%(V)
Water Solubility  25 g/L (20 ºC)
Merck  14,7511
BRN  969480
InChIKey IUGYQRQAERSCNH-UHFFFAOYSA-N
CAS DataBase Reference 75-98-9(CAS DataBase Reference)
NIST Chemistry Reference Pivalic acid(75-98-9)
EPA Substance Registry System Pivalic acid (75-98-9)
Safety Information
Hazard Codes  C
Risk Statements  21/22-34
Safety Statements  26-36/37/39-45
RIDADR  UN 3261 8/PG 2
WGK Germany  1
RTECS  TO7700000
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29159000
Hazardous Substances Data 75-98-9(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 900 mg/kg LD50 dermal Rat 1900 mg/kg

Pivalic acid Usage And Synthesis
Chemical Properties white crystalline low melting mass
Uses Pivalic Acid is a metabolite of oral cephem (β-lactam) antibiotics such as S-1108, containing pivaloyl moieties.
General Description Pivalic acid is a colored crystalline solid of low toxicity that is soluble in water, ethyl alcohol and diethyl ether.
Air & Water Reactions With mixing, water soluble.
Reactivity Profile Pivalic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Pivalic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.