578-86-9 LIQUIRITIGENIN

Superiority:

LIQUIRITIGENIN Basic information
Description References
Product Name: LIQUIRITIGENIN
Synonyms: good price Liquiritigenin 578-86-9;4',7-DIHYDROXYFLAVANONE;7,4'-DIHYDROXYFLAVANONE;LIQUIRITIGENIN;LIQUIRITIGENIN(P);LIQUIRITIGENIN WITH HPLC;7,4''-DIHYDROXYFLAVANONE hplc;(2S)-2α-(4-Hydroxyphenyl)-7-hydroxy-2,3-dihydro-4H-1-benzopyran-4-one
CAS: 578-86-9
MF: C15H12O4
MW: 256.25
EINECS:
Product Categories: Flavanones;sy;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File: 578-86-9.mol

LIQUIRITIGENIN Chemical Properties
Melting point  206-208°C
Boiling point  529.5±50.0 °C(Predicted)
density  1.386±0.06 g/cm3(Predicted)
Fp  207℃
pka 7.71±0.40(Predicted)
BRN  359378
InChIKey FURUXTVZLHCCNA-AWEZNQCLSA-N
Safety Information
WGK Germany  3
HS Code  29329990

LIQUIRITIGENIN Usage And Synthesis
Description Liquiritigenin is an active estrogenic component in extracts of Glycyrrhizae radix. Glycyrrhizae radix (G. radix, licorice, liquorice) is frequently used for life-enhancing properties, for the treatment of injury or swelling, for detoxification in traditional Oriental medicine, as well as a food supplement in many of the countries in the world.  Liquiritigenin is a selective estrogen receptor-β (ERβ) agonist.  Liquiritigenin activates multiple ER regulatory elements and native target genes with ERβ but not ERα. The ERβ-selectivity of liquiritigenin is due to the selective recruitment of the coactivator steroid receptor coactivator-2 to target genes.
As the targeting ERβ is associated with anti-inflammatory effects, liquiritigenin exerts anti-inflammatory effects. Liquiritigenin is also reported to antihyperlipidemic, antiallergic and antihepatocellular carcinoma effects.