109-43-3 Dibutyl sebacate

Superiority:

Product Name: Dibutyl sebacate
Synonyms: Dibutyl sebacinate;dibutyl1,8-octanedicarboxylate;Dibutylester kyseliny sebakove;dibutylesterkyselinysebakove;Kodaflex DBS;kodaflexdbs;Monoplex dbs;monoplexdbs
CAS: 109-43-3
MF: C18H34O4
MW: 314.46
EINECS: 207-395-0
Product Categories: pharmacetical;Piperazine derivates;Fatty Acid Esters (Plasticizer);Functional Materials;Plasticizer
Mol File: 109-43-3.mol
Dibutyl sebacate Chemical Properties
Melting point  205 °C (dec.)(lit.)
Boiling point  178-179 °C3 mm Hg(lit.)
density  0.94
FEMA  2373 | DIBUTYL SEBACATE
refractive index  n20/D 1.441(lit.)
Fp  >230 °F
solubility  hexane, toluene, ethanol and acetone: soluble
form  Liquid
Specific Gravity 0.937 (20/4℃)
color  Clear
Water Solubility  50mg/L(temperature not stated)
JECFA Number 625
BRN  1798308
CAS DataBase Reference 109-43-3(CAS DataBase Reference)
NIST Chemistry Reference Di-n-butyl sebacate(109-43-3)
EPA Substance Registry System Dibutyl sebacate (109-43-3)
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  40-36/37/38
Safety Statements  36/37-36-26
WGK Germany  3
RTECS  VS1150000
TSCA  Yes
HS Code  29171390
Hazardous Substances Data 109-43-3(Hazardous Substances Data)
Toxicity LD50 oral in rat: 14870mg/kg
Dibutyl sebacate Usage And Synthesis
Chemical Properties clear liquid
Chemical Properties Dibutyl sebacate is a clear, colorless, oily liquid with a bland to slight butyl odor.
Uses Dibutyl sebacate (DBS) is a dibutyl ester of sebacic acid. Dibutyl sebacate can be used for plastics in use in the food packaging industry, in plastics used for medical devices, and for pharmaceutical applications. Dibutyl sebacate is also used as a desensitizer in Otto fuel II, a torpedo monopropellant.
Production Methods Dibutyl sebacate is manufactured by the esterification of n-butanol and sebacic acid in the presence of a suitable catalyst, and by the distillation of sebacic acid with n-butanol in the presence of concentrated acid.
Preparation By distillation of sebacic acid with butyl alcohol in the presence of concentrated HCl in benzene solution or by reacting butyl alcohol and sebacyl chloride
Pharmaceutical Applications Dibutyl sebacate is used in oral pharmaceutical formulations as a plasticizer for film coatings on tablets, beads, and granules, at concentrations of 10–30% by weight of polymer. It is also used as a plasticizer in controlled-release tablets and microcapsule preparations.
Dibutyl sebacate is also used as a synthetic flavor and flavor adjuvant in food products;for example,up to 5ppm is used in ice cream and nonalcoholic beverages.
Safety Profile Mddly toxic by ingestion. Experimental reproductive effects. Combustible liquid when exposed to heat or flame; can react with oxidzing materials. To fight fire, use CO2 position it emits acrid smoke and fumes. See also ESTERS and n-BUTYL. ALCOHOL.