114084-78-5 Ibandronic acid

Superiority:

Product Name: Ibandronic acid
Synonyms: Ibandronate Acid;[1-Hydroxy-3-(MethylpentylaMino)propylidene]diphosphonic Acid;BPH 24;(1-Hydroxy-3-(Methyl(pentyl)aMino)propane-1,1-diyl)diphosphonic acid;IBANDRONIC ACID-D3;{1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphnic Acid;[1-Hydroxy-3-(methyl-d3-pentylamino)propylidene]bisphosphnic Acid;Ibandronic
CAS: 114084-78-5
MF: C9H23NO7P2
MW: 319.23
EINECS:
Product Categories: anti-osteoporosis;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Phosphorylating and Phosphitylating Agents
Mol File: 114084-78-5.mol

Ibandronic acid Chemical Properties
Melting point  113-115°C
Boiling point  587.8±60.0 °C(Predicted)
density  1.449±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer
pka 1.60±0.10(Predicted)
CAS DataBase Reference 114084-78-5(CAS DataBase Reference)
EPA Substance Registry System Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis- (114084-78-5)

Ibandronic acid Usage And Synthesis
Description This third generation biphosphonate was launched in Austria and Germany for the treatment of bone disorders such as hypercalcemia in malignancy and ostedysis, Paget's disease and osteoporosis. It does not effect bone mineralization, therefore, the potential risk of osteomalacia is prevented. This was a problem with first generation derivatives. While the exact mode of action is not understood, they are inhibitors of osteroclast mediated bone resorption. These compounds strongly interact with hydroxyapatite crystals and have a half-life in the skeleton of several years. Despite this observation ibandronate was well tolerated and safe.
Chemical Properties White Solid
Originator Boehringer Mannheim (Germany)
Uses A biphosphonate bone resorption inhibitor.
Uses A labeled biphosphonate bone resorption inhibitor.
Uses A bisphosphonate antiresorptive agent. Bone resorption inhibitor.
Brand name Bondronat