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375-22-4 Heptafluorobutyric acid 375-22-4 Heptafluorobutyric acid 375-22-4 Heptafluorobutyric acid
Product Name: Heptafluorobutyric acid
Synonyms: 2,2,3,3,4,4,4-heptafluorobutanoate;uorobutyric acid;Heptafluorobutyric Acid (ca. 0.5mol/L in Water) [Ion-Pair Reagent for LC-MS];PERFLUOROBUTYRATE;Heptafluorobutyricacid99%;Heptafluorobutyric acid, for protein sequence analysis, 99%;HAPTAFLUORO-N-BUTYRIC ACID;HEPTAFLUOROBUTYRIC ACID, FOR PROTEIN SEQ UENTIAL ANALYSIS
CAS: 375-22-4
MF: C4HF7O2
MW: 214.04
EINECS: 206-786-3
Product Categories: GC Derivatizing Reagents;HPLC and LCMS Mobile Phase Additive;Pharmaceutical Intermediates;Analytical Chemistry;Ion-Pair Reagents for HPLC;LC/MS Ion-Pair Reagents for Basic Samples;Acylation (GC Derivatizing Reagents)
Mol File: 375-22-4.mol
Heptafluorobutyric acid Chemical Properties
Melting point -17.5 °C
Boiling point 120 °C755 mm Hg(lit.)
density 1.645 g/mL at 25 °C(lit.)
vapor density 7 (vs air)
vapor pressure ~10 mm Hg ( 25 °C)
refractive index n20/D 1.3(lit.)
Fp 120-121°C
storage temp. 2-8°C
pka pK1:0.17 (25°C)
form Powder
color Clear colorless to faint yellow
Specific Gravity approximate 1.6
PH 1 (H2O, 20℃)
Water Solubility miscible
Sensitive Light Sensitive
BRN 1426882
InChIKey YPJUNDFVDDCYIH-UHFFFAOYSA-N
CAS DataBase Reference 375-22-4(CAS DataBase Reference)
NIST Chemistry Reference Butanoic acid, heptafluoro-(375-22-4)
EPA Substance Registry System Heptafluorobutyric acid (375-22-4)
Safety Information
Hazard Codes C
Risk Statements 34-35
Safety Statements 26-36/37/39-45
RIDADR UN 3265 8/PG 2
WGK Germany 3
RTECS ET4025000
F 3-8-10
Hazard Note Corrosive
TSCA T
HazardClass 8
PackingGroup II
HS Code 29159000
Heptafluorobutyric acid Usage And Synthesis
Chemical Properties Clear colorless to faintly yellow liquid
Uses Heptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.
Product Name: Heptafluorobutyric acid
Synonyms: 2,2,3,3,4,4,4-heptafluorobutanoate;uorobutyric acid;Heptafluorobutyric Acid (ca. 0.5mol/L in Water) [Ion-Pair Reagent for LC-MS];PERFLUOROBUTYRATE;Heptafluorobutyricacid99%;Heptafluorobutyric acid, for protein sequence analysis, 99%;HAPTAFLUORO-N-BUTYRIC ACID;HEPTAFLUOROBUTYRIC ACID, FOR PROTEIN SEQ UENTIAL ANALYSIS
CAS: 375-22-4
MF: C4HF7O2
MW: 214.04
EINECS: 206-786-3
Product Categories: GC Derivatizing Reagents;HPLC and LCMS Mobile Phase Additive;Pharmaceutical Intermediates;Analytical Chemistry;Ion-Pair Reagents for HPLC;LC/MS Ion-Pair Reagents for Basic Samples;Acylation (GC Derivatizing Reagents)
Mol File: 375-22-4.mol
Heptafluorobutyric acid Chemical Properties
Melting point -17.5 °C
Boiling point 120 °C755 mm Hg(lit.)
density 1.645 g/mL at 25 °C(lit.)
vapor density 7 (vs air)
vapor pressure ~10 mm Hg ( 25 °C)
refractive index n20/D 1.3(lit.)
Fp 120-121°C
storage temp. 2-8°C
pka pK1:0.17 (25°C)
form Powder
color Clear colorless to faint yellow
Specific Gravity approximate 1.6
PH 1 (H2O, 20℃)
Water Solubility miscible
Sensitive Light Sensitive
BRN 1426882
InChIKey YPJUNDFVDDCYIH-UHFFFAOYSA-N
CAS DataBase Reference 375-22-4(CAS DataBase Reference)
NIST Chemistry Reference Butanoic acid, heptafluoro-(375-22-4)
EPA Substance Registry System Heptafluorobutyric acid (375-22-4)
Safety Information
Hazard Codes C
Risk Statements 34-35
Safety Statements 26-36/37/39-45
RIDADR UN 3265 8/PG 2
WGK Germany 3
RTECS ET4025000
F 3-8-10
Hazard Note Corrosive
TSCA T
HazardClass 8
PackingGroup II
HS Code 29159000
Heptafluorobutyric acid Usage And Synthesis
Chemical Properties Clear colorless to faintly yellow liquid
Uses Heptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.
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