82186-77-4 Lumefantrine 82186-77-4 Lumefantrine 82186-77-4 Lumefantrine
Product Name: Lumefantrine
Synonyms: (9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol;CPG-56695;Benwuchun;Benflumentol;benflumetol;Lumefantrine;BENFLUMETOL (OR LUMEFANTRINE);(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-a-[(dibutylamino)methyl]-9H-fluorene-4-methanol
CAS: 82186-77-4
MF: C30H32Cl3NO
MW: 528.94018
EINECS: 617-303-4
Product Categories: Pharmaceutical intermediates;Antibiotics;API;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 82186-77-4.mol
Lumefantrine Chemical Properties
Melting point 129-131°C
Boiling point 642.5±55.0 °C(Predicted)
density 1.252
storage temp. Refrigerator
solubility DMSO: ≥20mg/mL
form powder
pka 13.44±0.20(Predicted)
color yellow
Merck 14,5597
CAS DataBase Reference 82186-77-4(CAS DataBase Reference)
Safety Information
WGK Germany 3
HS Code 29221950
Hazardous Substances Data 82186-77-4(Hazardous Substances Data)
Lumefantrine Usage And Synthesis
Antimalarial drug Benflumetol and artemether are the widely used antimalarial drugs currently in clinical , they are the main ingredients of the well-known anti-malarial drugs called Compound artemether of Novartis ,which can kill plasmodia asexual, insecticidal rate is high, the cure rate is about 95%, but it is invalid in the pre-erythrocytic stage and gametophyte . Animal experiments suggest it is drug with micro toxicity,but the mutagenic and teratogenic tests are negative. It is mainly used for the treatment of falciparum malaria in clinical, especially for the chloroquine-resistant falciparum malaria treatment.
Product Name: Lumefantrine
Synonyms: (9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol;CPG-56695;Benwuchun;Benflumentol;benflumetol;Lumefantrine;BENFLUMETOL (OR LUMEFANTRINE);(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-a-[(dibutylamino)methyl]-9H-fluorene-4-methanol
CAS: 82186-77-4
MF: C30H32Cl3NO
MW: 528.94018
EINECS: 617-303-4
Product Categories: Pharmaceutical intermediates;Antibiotics;API;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 82186-77-4.mol
Lumefantrine Chemical Properties
Melting point 129-131°C
Boiling point 642.5±55.0 °C(Predicted)
density 1.252
storage temp. Refrigerator
solubility DMSO: ≥20mg/mL
form powder
pka 13.44±0.20(Predicted)
color yellow
Merck 14,5597
CAS DataBase Reference 82186-77-4(CAS DataBase Reference)
Safety Information
WGK Germany 3
HS Code 29221950
Hazardous Substances Data 82186-77-4(Hazardous Substances Data)
Lumefantrine Usage And Synthesis
Antimalarial drug Benflumetol and artemether are the widely used antimalarial drugs currently in clinical , they are the main ingredients of the well-known anti-malarial drugs called Compound artemether of Novartis ,which can kill plasmodia asexual, insecticidal rate is high, the cure rate is about 95%, but it is invalid in the pre-erythrocytic stage and gametophyte . Animal experiments suggest it is drug with micro toxicity,but the mutagenic and teratogenic tests are negative. It is mainly used for the treatment of falciparum malaria in clinical, especially for the chloroquine-resistant falciparum malaria treatment.
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