54-62-6 Aminopterin

Superiority:

Product Name: Aminopterin
Synonyms: nsc739;AMINOPTERIN;AMINOPTERINE;4-AMINO-PGA;4-AMINOFOLIC ACID;4-AMINOPTEROYLGLUTAMIC ACID;4-AMINOPTEROYL-L-GLUTAMIC ACID;(S)-2-{4-[2,4-diaMinopteridin-6yl)MethylaMino]benzoaMido}pentanedioic acid
CAS: 54-62-6
MF: C19H20N8O5
MW: 440.41
EINECS: 200-209-9
Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Aromatics;Inhibitors
Mol File: 54-62-6.mol

Aminopterin Chemical Properties
Melting point  228-235 °C (dec.)
alpha  18 º (c=1% in 0.1N NaOH)
Boiling point  551.67°C (rough estimate)
density  1.4378 (rough estimate)
refractive index  1.6910 (estimate)
Fp  87℃
storage temp.  2-8°C
solubility  2 M NaOH: 50 mg/mL
pka pKa 5.5 (Uncertain)
form  powder
color  yellow
Merck  14,472
BRN  69045
CAS DataBase Reference 54-62-6(CAS DataBase Reference)
EPA Substance Registry System Aminopterin (54-62-6)
Safety Information
Hazard Codes  T+
Risk Statements  61-28-63-26/27/28
Safety Statements  53-28-36/37-45-36/37/39-22
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS  MA1050000
F  8-10-23
HazardClass  6.1(a)
PackingGroup  I
HS Code  29339900
Hazardous Substances Data 54-62-6(Hazardous Substances Data)
Toxicity LDLo orl-rat: 2500 mg/kg JPETAB 95,303,49

Aminopterin Usage And Synthesis
Chemical Properties Dark Yellow Solid
Chemical Properties Aminopterin is a white to yellow powder; commonly used as the dihydrate which forms clustersof yellow needles
Uses A folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
Uses antineoplastic, antirheumatic, folic acid antagonist
Definition Differs slightly in structure from folic acid and antagonizes the utilization of folic acid by the body, an antimetabolite.
General Description Clusters of yellow needles. Used as a rodenticide, medicine and rodenticide. Not registered as a rodenticide in the U.S.
Health Hazard An antimetabolite; antagonizes the utilization of folic acid by the body. Highly toxic by ingestion.