Fexofenadine hydrochloride Basic informationDescription References
Product Name:Fexofenadine hydrochlorideSynonyms:FEXOFENADINE-D10 HCL;α,α-dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]benzeneacetic acid;Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride;MDL 16455A;Telfast;Telfast BD;2-[4-[1-Hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride;AllegraCAS:153439-40-8MF:C32H40ClNO4MW:538.12EINECS:Product Categories:Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;Aromatics;Heterocycles;Metabolites & Impurities;APIMol File:153439-40-8.mol
Fexofenadine hydrochloride Chemical Properties
Melting point 148-150oCstorage temp. −20°CCAS DataBase Reference153439-40-8(CAS DataBase Reference)
Safety Information
Hazard Codes XiRisk Statements 36/37/38Safety Statements 26-36
MSDS Information
Fexofenadine hydrochloride Usage And Synthesis
DescriptionFexofenadine hydrochloride (trade name: Allegra) belongs to a second-generation antihistamine pharmaceutical drug. It is mainly used for the treatment of allergy symptoms including watery eyes, hay fever, nasal congestion, urticaria, runny nose, itching eyes/nose, sneezing, hives, and itching. It is a kind of selectively peripheral H1 blocker. Its mechanism of action in vivo is through preventing the histamine-mediated activation of the H1 receptors, thus alleviating the symptoms related to allergy. Compared to the first-generation antihistamine drug, it is less prone to penetrate the blood-brain barrier, reducing the possibility to cause side effects such as drowsiness.Referenceshttp://www.rxlist.com/allegra-drug/consumer-uses.htm
#;PropertiesOff-White Crystalline SolidUsageA metabolite of of terfenadine, a H1-Histamine receptor antagonistUsageThe active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist.UsageAntihistaminic;histamine H1-receptor antagonistBiological ActivitySelective histamine H 1 receptor antagonist (pK i = 8.1). Active metabolite of terfenadine that displays non-sedating antiallergic effects.牋.