High purity Pyrimethamine for antifungal drugs with good quality

Product Name:

Pyrimethamine

Synonyms:

2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine;2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-;2,4-Pyrimidinediamine, 5-(p-chlorophenyl)-6-ethyl-;2,4-Pyrimidinediamine,5-(4-chlorophenyl)-6-ethyl-;4753 R.P.;4753r.p.;5-(4’-chlorophenyl)-2,4-diamino-6-ethylpyrimidine

CAS:

58-14-0

MF:

C12H13ClN4

MW:

248.71

Product Categories:

APIs & Intermediate;Pyrimidine;Organics;Amines;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Inhibitor;Heterocycle-Pyrimidine series;DARAPRIM

Mol File:

58-14-0.mol

Chemical Properties

melting point 

233-234°C

boiling point 

491.5 °C at 760 mmHg

density 

1.305 g/cm3

flashing point 

251 °C

vapor pressure 

8.34E-10 mmHg at 25°C

storage temp. 

0-6°C

Water Solubility 

<0.01 g/100 mL at 21 ºC

Stability

Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.

Usage And Synthesis

Chemical Properties

White Solid

Usage

Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial

For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Pyrimethamine is sensitive to exposure to light . Neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Fire Hazard

Flash point data for Pyrimethamine are not available; however, Pyrimethamine is probably combustible.

Biological Activity

Potent inhibitor of multi-drug and toxin extrusion (MATE) transporters (K i values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR).