High purity Doxazosin mesylate with good quality

Product Name:

Doxazosin mesylate

Synonyms:

1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-[4-(1,4-BENZODIOXAN-2-YL)CARPIPERAZIN-1-YL)]-6,7-DIMETHOXYQUINAZOLINE MESYLATE;1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piperazine methanesulfonate;ALFADIL;CARDURA;CARDENALIN;DOXAZOSIN MESYLATE;DOXAZOSIN METHANESULFONATE;UK-33274-27

CAS:

77883-43-3

MF:

C24H29N5O8S

MW:

547.58

Product Categories:

Active Pharmaceutical Ingredients;Antihypertensive;Intermediates & Fine Chemicals;Pharmaceuticals;Adrenoceptor;CARDURA;Cardiovascular APIs;Inhibitors

Mol File:

77883-43-3.mol

Chemical Properties

melting point 

275-277°C

boiling point 

718 °C at 760 mmHg

flashing point 

388 °C

vapor pressure 

1.83E-20 mmHg at 25°C

storage temp. 

Desiccate at RT

Stability

Protect from light

Quality Index

Related Substance：

A ≤0.3% total impurite ≤1.0%

Loss on Drying：

≤2.0%

Residue on Ignition：

≤0.1%

Heavy Metal：

≤10ppm

Content：

98.0%~102.0%

conclusion

(USP31) （BP2008）

Usage And Synthesis

Chemical Properties

White Crystalline Powder

Usage

A selective α-1-adrenergicblocker related to prazosin.

antihypertensive

Doxazosin is a selective α1-adrenoceptor antagonist. Doxazosin relaxes smooth muscles of the prostate.

Doxazosin ER is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia

Biological Activity

Selective α 1 -adrenoceptor antagonist (pK i values are 9.0, 8.5 and 8.4 for human α 1B , α 1A and α 1D receptors respectively). Displays antihypertensive activity.