High purity Genistein with best price and good quality

Product Name:

Genistein

Synonyms:

4’,5,7-trihydroxy-isoflavon;5,7-dihydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;c.i.75610;differenola;genistein(synthetic);genisteol;genisterin;prunetol

CAS:

446-72-0

MF:

C15H10O5

MW:

270.24

Product Categories:

pharmacetical;Biochemistry;Flavonoids;Natural Plant Extract;The group of Daidzin;Inhibitors;Tyrosine Kinase Inhibitors;Protein Kinase;Signalling;Plant extract;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;standardized herbal extract;inhibitor

Mol File:

446-72-0.mol

Chemical Properties

melting point 

297-298 °C

boiling point 

555.5 °C at 760 mmHg

density 

1.548 g/cm3

flashing point 

217.1 °C

vapor pressure 

6E-13 mmHg at 25°C

storage temp. 

−20°C

solubility 

DMSO: soluble

Water Solubility 

insoluble

Stability

Light Sensitive

Usage And Synthesis

Chemical Properties

Yellow Crystalline Solid

Usage

Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol

Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.

cytotoxic inhibitor of tyrosine kinase and topoisomerase II kinase