171228-49-2 Posaconazole Posaconazole 171228-49-2 antifungal
Prroduct Name: Posaconazole
CAS: 171228-49-2
MF: C37H42F2N8O4
MW: 700.78
Alisa: Posaconazole;2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol;Noxafil;Sch 56592;4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one;HYDROXYPROPYL]-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE;Posaconazole for research;1-((1S,2S)-1-Ethyl-2-hydroxypropyl)-4-{4-[4-(4-{[(5S,3R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazolylmethyl)oxolan-3-yl]methoxy}phenyl)piperazinyl]phenyl}-1,2,4-triazolin-5-one
Structure:
Assay: ≥99.0 %
Posaconazole Test standard:
Test Item |
Test Specification |
Appearance |
White powder |
Purity ( HPLC ) |
≥ 99.5%min |
Max single impurity |
≤ 0.1% |
Residual on ignition |
≤ 0.3% |
Loss on drying |
≤ 0.5% |
Water |
≤ 0.5% |
Heavy metal |
≤ 10ppm |
Indications:Posaconazole is a broadspectrum triazole active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14ademethylase enzyme (IC50s range from 7-200 nM), which results in a disruption the synthesis of ergosterol, a key sterol necessary for fungal
cell membrane integrity and for the function of certain membranebound proteins
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