150399-23-8 2-[4-[2-(4-Amino-2-oxo-3,5,7-triazabicyclo[4.3.0]nona-3,8,10-trien-9-yl)ethyl]benzoyl]aminopentanedioic acid disodium salt N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-D-glutamic acid
Pemetrexed Disodium cas 150399-23-8 belongs to a class of chemotherapeutic drugs called folic metabolites . It is prescribed for the treatment of pleural mesothelioma and nonsmall cell lung cancer. By inhibiting the formation of purine and pyrimidine nucleotides, Pemetrexed Disodium cas 150399-23-8 prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.
During this medication therapy it is considered to produce side effects such as low blood counts, mental fatigue and sleepiness, nausea, vomiting and skin rashes. Pemetrexed Disodium cas 150399-23-8 is contraindicated in patients with severe liver diseases.
Test Items |
Standard |
Test Results |
Character |
Almost-white or light yellow unfixed powder, smell-less, hygroscopic freely. |
white unfixed powder, smell-less, hygroscopic freely. |
Solubility |
Soluble in water very freely, hardly soluble in ethanol or chloroform or ethyl ether. |
Conforms |
PH |
6.5-8.5 |
7.2 |
Clarity and color of solution |
Meet the requirements. |
Conforms |
Related substance |
Max single impurity≤0.1% |
0.036% |
Total impurity≤0.5% |
0.17% |
|
Heavy Metal |
<20ppm |
Conforms |
Water |
7.2%-10.2% |
8.8% |
Chloride |
≤0.02% |
Conforms |
Ethanol |
≤5000ppm |
1687ppm |
Dichloromethane |
≤600ppm |
Not Detected |
N,N-Dimethylformamide |
≤880ppm |
Not Detected |
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