Granisetron 109889-09-0

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price: USD 1.0000

1 Kilogram

FOB Price: USD 1.0000

Min.Order :1 Kilogram
Purity: 99%min
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

109889-09-0 Granisetron granisetron hydrochloride

Quick Details

Appearance:White or almost white powder
Application:Central Nervous System Drug; Anti-Emetic and Antinauseant
PackAge:25Kg/Drum
ProductionCapacity:2000|Kilogram|Week
Storage: Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Transportation:by sea,air

Superiority:

Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting followingchemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.
Granisetron was developed by chemists working at the British drug company Beecham around 1988 and is available as a generic. It is produced by Roche Laboratories under the trade name Kytril. The drug was approved in the United Kingdomin 1991 and in United States in 1994 by the FDA.
A granisetron transdermal patch with the trade name Sancuso was approved by the US FDA on September 12, 2008.[1] Sancuso is manufactured by ProStrakan, Inc., a pharmaceutical company headquartered in Bedminster, NJ, with global headquarters in Scotland.
Granisetron is metabolized slowly by the liver, giving it a longer than average half-life. One dose usually lasts 4 to 9 hours and is usually administered once or twice daily. This drug is removed from the body by the liver and kidneys.

Details:

Items	Specifications	Results
Appearance	White or almost white powder	Comlies
Solubility	Freely soluble in water, sparingly soluble in methylene chloride, slightly soluble in Methanol.	complies
Identification	a) Infrared absorption spectrophtometry Comaprison: Granisetron Hydrochloride CRS b) It gives reaction (a) of chloride	complies
a) Solution S	Concordant with R.S	complies
b) Appearance of solution	Concordant with R.S	complies
c) pH	4.0 to 6.5	4.6
d) Impurity E	<0.5%	complies
Related substance	Total <1.0%	0.20%
	Impurity A ≤1.0%	0.02%
	Impurity B ≤0.5%	0.02%
	Impurity C ≤0.2%	0.02%
	Impurity D ≤0.1%	0.02%
	Any other impurity≤0.1%	0.02%
	Total ≤1.0%	0.01%
Heavy metal	≤10ppm	<10ppm
Sulphated ash	<0.1%	0.06%
Loss on drying	<0.5%	<0.1%
Residual Solvents	methanol<0.3%	0.01%
Bacterialendotoxins	<0.05EU/mg	<0.05EU/mg
Assay	97%~102%	100.60%
Conclusion	The results comply with the requirement of the EP7