- Min.Order :1 Metric Ton
- Purity: 99%min
- Payment Terms : L/C,T/T
Keywords
170729-80-3 Aprepitant 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1,2-dihydro-3H-1,2,4-triazol-3-one
Quick Details
- Appearance:White powder
- Application:Central Nervous System Drug; Anti-Emetic and Antinauseant
- PackAge:drum
- ProductionCapacity:1000|Metric Ton|Year
- Storage:Store in cool and dry place, away from sun light.
- Transportation:By sea or by air
Superiority:
| Name |
Aprepitant |
| CAS No | 170729-80-3 |
| MF | C23H21F7N4O3 |
| Purity | 99% |
| Appearance | white powder |
Details:
|
Item |
Specification |
Test Results |
||
|
Description |
Off-white to light yellow powder |
Conforms |
||
|
Identification IR |
HPLC, IR |
Conform |
||
|
Specific optical rotation |
+68.0° ±3° (c=1.0, in Methanol) |
67.49° |
||
|
Melting point |
248±5 °C |
248 -250°C |
||
|
Water |
≤0.5% |
0.29% |
||
|
Heavy metals |
≤10ppm |
Conforms |
||
|
Residue on ignition |
Not more than 0.1% |
0.07% |
||
|
Related substances |
Desfluoro aprepitant NMT 0.15% R,R,R-Diastereomer: NMT 0.15% Any other individual impurity: NMT 0.10% Total impurities: NMT 0.50% |
0.09% 0.08% 0.06% 0.29% |
||
|
Enantiomer purity |
NMT 0.15% of the S,R,S-enantiomer |
0.07% |
||
|
Assay (HPLC) |
NLT 98.0% and NMT 102.0% (on the anhydrous basis) |
99.9% |
||
|
Organic volatile impurities |
Methanol NMT 2500 ppm; Xylene NMT 2170 ppm; Toluene NMT 890 ppm; DMSO NMT 5000ppm |
Conforms |
||
|
Conclusion: Conforms to Authorized USP Pending Monograph |
||||
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