Calcipotriene

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1 Kilogram	FOB Price: USD 1.0000

1 Kilogram

FOB Price: USD 1.0000

112965-21-6 Calcipotriene dovonex

Name		Calcipotriene
Synonyms		(1S,3S,5Z)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(E,2S)-5-Cyclopropyl-5-hydroxy-pent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol


Molecular Formula		C27H40O3
Molecular Weight		412.61
CAS Registry Number		112965-21-6

Standard	EP6.0
Items	Specification	Results
Appearance	White or almost white, crystalline powder	Complies
Solubility	Practically insoluble in water, freely soluble in ethanol,(96%), slightly soluble in methylene chloride (96 percent), slightly soluble in methylene chloride	Complies
Identification	Infrared spectrum corresponds to that of the standard preparation	Complies
Identification	The retention time of the major peak in the chromatogram corresponds to that in the chromatogram of standard preparation	Complies
Related Substances by TLC	Impurity A ((5Z,7E,22E)-24-cyclopropyl-1α,3β-dihydroxy-9,10-secochola-5,7,10(19),22-tetraen-24-one): NMT 0.25%	Complies
	Impurity G (24,24-oxybis[(5Z,7E,22E,24S)-24-cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β-diol]) : NMT 0.25%	Complies
	Impurity H ((5Z,7E,22E,24R)-24-cyclopropyl-24- [[(5Z,7E,22E,24S)-24-cyclopropyl-1α,3β-dihydroxy-9,10-secochola-5,7,10(19),22-tetraen-24-yl]oxy]-9,10-secochola-5,7,10(19),22-tetraene-1α,3β-diol): NMT 0.25%	Complies
	Any other impurity : NMT 0.1%	Complies
Related Substances by HPLC	Impurity B ((7Z)-calcipotriol) : NMT 0.5%	ND
	Impurity C ((5E)-calcipotriol) : NMT 1.0%	0.50%
	Impurity D (24-epi-calcipotriol) : NMT 1.0%	0.66%
	Any other impurity: NMT 0.1%	0.09%
	Total impurities : NMT 2.5%	1.25%
Residual Solvents	Acetone : NMT 5000ppm	630ppm
	Ethyl acetate : NMT 5000ppm	ND
	n-Hexane : NMT 290ppm	ND
	Methanol : NMT 3000ppm	ND
	Dichloromethane : NMT 600ppm	ND
Loss on Drying	NMT 0.5%	0.27%
Content	95.5%-102.0% (dried substance)	98.26%