51146-56-6 Dexibuprofen (S)-(+)-Ibuprofen
Name: (S)-(+)-Ibuprofen
CAS No.: 51146-56-6
Formula: C13H18O2
Molecular Weight: 206.28
Synonyms: Benzeneaceticacid, a-methyl-4-(2-methylpropyl)-,(S)-;(+)-(S)-Ibuprofen;(+)-(S)-p-Isobutylhydratropic acid;(+)-Ibuprophen
Density: 1.029 g/cm3
Solubility: insoluble in water
Test Item |
Analysis Specification |
Result |
Description |
White crystalline power |
white crystalline power |
Identification |
A: IR the spectrum is concordant with the spectrum of (S)-ibuprofen RS B: The retention time of the principal peak is concordant with that of (S)-ibuprofen RS(HPLC) C: Show two maximum absorption at 265nm and 273nm, two minimum absorption at 245nm and 271nm and a shoulder peak at 259nm.(UV) |
Conforms
Conforms
Conforms
|
Melting point |
50~54°C |
50.8~52.7°C |
Optical rotation |
+55°~ +60° |
+58.2° |
Chloride |
≤0.01% |
<0.1% |
Loss on drying |
≤0.5% |
0.02% |
Residue on ignition |
≤0.1% |
0.01% |
Heavy metals |
≤10ppm |
<10ppm |
Residual solvents |
Toluene not more than 800 ppm |
3ppm |
Related Substances |
2-(4-butylphenyl)propionic acid <0.2% 4-isobutylacetophenone <0.2% Total impurities <0.7% Any other individual impurity <0.2% Any unidentified impurity <0.10% R-ibuprofen ≤1.5% |
Not detected Not detected 0.03% 0.02% Not detected Conforms |
Assay(Dry Basis) |
98.5%~101.0% |
99.2% |
Conclusion |
Conform to In house Standard |
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