142217-69-4 Entecavir entecavir Baraclude
CAS: 142217-69-4
English name: Entecavir
Molecular formula: C12H15N5O3: 277.28
Melting point: 249-252 ° C
Boiling point: 734.2 ° C at 760 mmHg
Refractive index: 1.837
Flash point: 397.9 ° C
Density: 1.81g / cm3
Appearance |
White to off-white powder |
Complies |
Optical rotation |
+24.0°—+28.0°(DMF:MeOH=1:1 c=1%) |
+26.8° |
Identification |
A: By IR, To match with working standard |
Complies |
B:By HPLC,retain time should match with working standard |
Complies |
|
Water |
5.8%—6.5% |
6.1% |
Isomer |
Single ≤0.1% |
0.02% |
Total ≤0.5% |
0.02% |
|
Related Substances |
Single impurity ≤0.1% |
0.02% |
Total impurities ≤0.3% |
0.03% |
|
Granularity |
Particle size D50≤6.0μm D90≤12.5μm |
Complies |
Residue on ignition |
≤0.1% |
0.06% |
Heavy metals |
£ 20ppm |
Complies |
Residual solvents |
Should be to match with the standard |
Complies |
Assay |
≥99.8% |
99.9% |
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