Sirolimus

Min.Order / FOB Price:Get Latest Price

100 Gram	FOB Price: USD 1.0000

100 Gram

FOB Price: USD 1.0000

Min.Order :100 Gram
Purity: 99%min
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

53123-88-9 Rapammune Rapamycin

Quick Details

Appearance:off-white or yellow crystalline powder
Application:Metabolism Drug; Immuno-suppressant
PackAge:on request
ProductionCapacity:100|Kilogram|Day
Storage:RT.
Transportation:by sea,air

Superiority:

Sirolimus (INN/USAN), also known as rapamycin, is a macrolide produced by the bacteria Streptomyces hygroscopicus. It has immunosuppressant functions in humans and is used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It prevents activation of T cells and B cells by inhibiting their response to interleukin-2 (IL-2). Sirolimus is also used as a coronary stent coating. Sirolimus works, in part, by eliminating old and abnormal white blood cells.[citation needed] Sirolimus is effective in mice with autoimmunity and in children with a rare condition called autoimmune lymphoproliferative syndrome (ALPS).

Details:

Item	Specification
Appearance	Odorless,off-white or yellow crystalline powder
Identification A	The IR spectrum of Potassium Bromide preparation of the sample exhibits maxima at the same wavelengths as that of a similar preparation of in-house reference standard
Identification B	The UV spectrum of 95% Ethanol preparation of the sample exhibits maxima at 267nm,277nm,288nm as that of a similar preparation of in-house reference standard
Identification C	The retention time of the peaks for the Trans-and Cis-stereoisomers in the chromatogram of Assay preparation corresponds to that in the chromatogram of the standard preparation,as obtained in the Assay
Loss on drying	≤ 0.5%
Heavy metals	≤ 0.002%
Chromatographic purity
Individual impurity	≤ 1.0%
Total impurities	≤ 2.0%
Cis-stereoisomer of sirolimus	≤ 5.0%
Assay	98.0-102.0% calculated trans-and cis-stereoisomers of sirolimus on the dried basis
Residual organic solvents
Ethanol	≤ 5000ppm
Ethyl acetate	≤ 5000ppm
Acetone	≤ 5000ppm