103628-48-4 methanesulfonamide succinate Sumatriptan succinate
Sumatriptan succinate is a selective 5-HT1 receptor agonist with specificity towards 5-HT1D, 5-HT1B and 5-HT1A. In addition, the
physicochemical properties of Sumatriptan succinate can be characterized using FT-IR, HPLC, SEM and XRD. It has been reported
that Sumatriptan succinate can be produced via reactive precipitation without the presence of surfactants. Further studies show that
molecules of Sumatriptan succinate are carried through cells using liposomes, with positively charged liposomes exhibiting the
highest loading efficiency.
Item |
Specifications |
Character |
Appearance: White or almost white powder. |
Solubility: Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride. |
|
Identification |
Infrared absorption spectrophotometry: corresponds to Sumatriptan succinate CRS. |
PH |
4.5~5.3 |
Absorbance: |
Maximum 0.10 |
Related substances |
Impurity A: not more than 0.6 percent |
Impurity H: not more than 0.3 percent |
|
Impurity B,C or D: each impurity not more than 0.5 percent |
|
Impurity E or any other impurity: each impurities not more than 0.1 percent |
|
Total impurities: not more than 0.6 percent |
|
Water |
not more than 1.0 percent |
Sulphated ash |
not more than 0.1 percent |
Residual solvents |
Methanol:not more than 3000ppm |
Acetonitrite:not more than 100ppm |
|
Isopropyl Alcohol:not more than 100ppm |
|
Chloroform:not more than 60ppm |
|
Assay |
97.5 percent to102.0 percent (Anhydrous substance). |
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