9039-53-6 Abbokinase Kinlytic
Urokinase CAS no 9039-53-6 antithrombotic
Alisa: EC 3.4.99.26;UROKINASE UPA 2-CHAIN;UROKINASE;UROKINASE 2-CHAIN;UROKINASE, HIGH MOLECULAR WEIGHT;UROKINASE, HIGH MW (URINE);UROKINASE, LOW MW (URINE);UROKINASE (MIXED)
CAS No: 9039-53-6
MF: C21H25BrN2O3
MW: 433.35
EINECS: 232-917-9
Urokinase Chemical Property:
Urokinase (UK) is a thrombolytic agent extracted from human fresh urine. It can activate plasminogen to plasmin, with the subsequent hydrolysis of fibrin and dissolution of thrombi.This product is mainly used in the treatment of acute myocardial infarction, acute cerebral thrombosis, occlusion of cerebral blood vessel, peripheral arteriovenous thrombi, central retinal arteriovenous thrombi and other infarction diseases due to freshly formed clot.Urokinase is produced by the human renal tubular epithelial cells of a serine protease, for an amorphous white powder, soluble in water. Dilute solution properties is not stable, must be fresh with, and shall not be diluted with acid solution. Freeze-dried state can be stable for several years. Isoelectric point PH8.4-8.7. Urokinase is very selective specificity of proteolytic enzymes. This article on the activity of synthetic substrate with trypsin and fibrinolytic enzyme approximation, also has the esterase vigor. No antigenicity, do not make the body to produce antibodies. The body t1/2 for 14 min + 6 min.
Urokinase Test Standard:
Appearance
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White or almost white, amorphous powder
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Identification
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Identified
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Activity
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Not less than 100,000 IU/mg
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Specific activity
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Not less than 120,000 IU/mg protein
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Clarity of solution
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Clear
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Thromboplastic contaminants
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Not less than 150 IU/ml
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HMW-Urokinase
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Not less than 90%
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Bacterial endotoxins
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Not more than 1.0 EU /10,000 IU
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Abnormal toxicity
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Negative at 5000 IU/0.5ml/mouse
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HIV I+II antibody
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Negative
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Hepatitis B surface antigen
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Negative
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HCV antibodies
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Negative
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