107753-78-6 Zafirlukast Cyclopentyl N-[3-{[2-methoxy-4-[(2-methylphenyl) sulfonylcarbamoyl]phenyl]methyl}-1-methyl-indol-5-yl]carbamate
Zafirlukast is a potent subtype specific cysteinyl leukotriene type 1 receptor (CysLT1) antagonist; antiasthmatic. The cysteinyl-
leukotrienes (CysLTs), LTC4 and LTD4, are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction,
augment microvascular permeability, and are vasoconstrictors of coronary arteries.
Items |
Specifications |
Results |
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Appearance |
White or light yellow powder |
White powder |
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Solubility |
Soluble in acetone,DMSO,HF; in soluble in water, methanol |
Complies |
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Identify 1 |
Maximum absorption wavelength: 240nm,300nm |
239nm,298nm |
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Identify 2 |
Content determination:conforms to spectrum |
Complies |
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Identify 3 |
IR: conforms to spectrum |
Complies |
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Chloride |
NMT 0.02% |
<0.02% |
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Sulfate |
NMT 0.04% |
<0.04% |
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Total impurities |
NMT 0.1% |
0.06% |
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Moisture |
NMT 1.0% |
0.38% |
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Loss on drying |
NMT 0.1% |
0.02% |
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Heavy metals |
NMT 20 ppm |
< 20 ppm |
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Content |
98.5%~101.5%( based on dry) |
99.9% |
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Conclusion |
Conform to CP 2010 |
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