Zafirlukast 107753-78-6

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1 Kilogram	FOB Price: USD 1.0000

1 Kilogram

FOB Price: USD 1.0000

107753-78-6 Zafirlukast Cyclopentyl N-[3-{[2-methoxy-4-[(2-methylphenyl) sulfonylcarbamoyl]phenyl]methyl}-1-methyl-indol-5-yl]carbamate

Zafirlukast is a potent subtype specific cysteinyl leukotriene type 1 receptor (CysLT1) antagonist; antiasthmatic. The cysteinyl-

leukotrienes (CysLTs), LTC4 and LTD4, are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction,

augment microvascular permeability, and are vasoconstrictors of coronary arteries.

Items	Specifications	Results
Appearance	White or light yellow powder	White powder
Solubility	Soluble in acetone,DMSO,HF; in soluble in water, methanol	Complies
Identify 1	Maximum absorption wavelength: 240nm,300nm	239nm,298nm
Identify 2	Content determination:conforms to spectrum	Complies
Identify 3	IR: conforms to spectrum	Complies
Chloride	NMT 0.02%	<0.02%
Sulfate	NMT 0.04%	<0.04%
Total impurities	NMT 0.1%	0.06%
Moisture	NMT 1.0%	0.38%
Loss on drying	NMT 0.1%	0.02%
Heavy metals	NMT 20 ppm	< 20 ppm
Content	98.5%~101.5%( based on dry)	99.9%
Conclusion	Conform to CP 2010