Irsogladine maleate C13H11Cl2N5O4

Superiority:

Product Name: Irsogladine maleate
Synonyms: 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinemaleate;2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinmaleate;3,5-triazine-2,4-diamine,6-(2,5-dichlorophenyl)-(z)-2-butenedioate(1:1);gaslon;mn-1695;2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine maleate;Irsogladin maleate;Gaslon N
CAS: 84504-69-8
MF: C13H11Cl2N5O4
MW: 372.16
EINECS:
Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 84504-69-8.mol
Irsogladine maleate Structure
Irsogladine maleate Chemical Properties
Melting point  181-182°C
storage temp.  Desiccate at RT
form  White crystalline powder.
Merck  14,5102
CAS DataBase Reference 84504-69-8(CAS DataBase Reference)
Safety Information
RTECS  XY5930000
Toxicity LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)

Irsogladine maleate Usage And Synthesis
Chemical Properties White Solid
Uses An anti-ulcer drug.
Uses antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication
Biological Activity Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.