High purity Apigenin with best price and good quality

Product Name:

Apigenin

Synonyms:

APIGENIN;CHAMOMILE;4',5,7-TRIHYDROXYFLAVONE;4,5,7-TRIHYDROXYFLAVONE;4',5,7-TRIHYROXYFLAVONE;5,7,4'-TRIHYDROXYFLAVONE;5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE;7,4',5-TRIHYDROXYFLAVONE

CAS:

520-36-5

MF:

C15H10O5

MW:

270.24

Product Categories:

Tri-substituted Flavones;Biochemistry;Flavonoids;Natural Plant Extract;Inhibitors;Protein Kinase;Signalling;chemical reagent;pharmaceutical intermediate;phytochemical;standardized herbal extract;natural product;Plant extract

Mol File:

520-36-5.mol

Chemical Properties

melting point 

>300 °C(lit.)

boiling point 

555.5 °C at 760 mmHg

density 

1.548 g/cm3

flashing point 

217 °C

vapor pressure 

0 mmHg at 25°C

storage temp. 

−20°C

solubility 

DMSO: 27 mg/mL

Usage And Synthesis

Chemical Properties

Pale Yellow Crystalline Solid

Usage

antispasmodic, antineoplastic, topoisomerase I inhibitor

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tum or cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap juntion intracellular communication in liver cells.

Biological Activity

Protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC 50 values are 59.44 and 31.15 μ M at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo.