Camptothecin (+)-Camptothecin Camptothecinum
Name: (+)-Camptothecin
CAS No.: 7689-03-4
Molecular Structure:
Formula: C20H16N2O4
Molecular Weight: 348.38
Synonyms: (S)-(+)-Camptothecin;Camptothecin;Camptothecinum;Campthecin;Camptothecine;4(S)-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14 (4H,12H)-dione;Camptothecine(CPT);
EINECS: 444-280-6
Density: 1.513 g/cm3
Melting Point: 260 °C (dec.)(lit.)
Boiling Point: 757.01 °C at 760 mmHg
Flash Point: 411.625 °C
Solubility: insoluble in water
Appearance: light yellow crystal powder
Natural camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.
Function
1. Anti-tumor;
2. Anti-leukemie;
3. Anti-virus;
4. Prevent from early pregnancy;
5. Improve the cutinization of skin.
Applications
1.Camptothecin can make changes in skin epidermal keratinization process.
2.Camptothecin is used for anti-cancer, anti-virus, immune inhibition, anti early pregnancy.
3.Camptothecin has the function of treatment of gastric cancer, liver cancer, head and neck cancer and leukemia,with fewer side effects than camptothecine.
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