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buy high purity Lubiprostone good producer

Lubiprostone (brand name: Amitiza) is a drug that is prescribed as a treatment for acute idiopathic constipation that is associated with bloating, stomach pain and straining in bowel movements. The drug is prescribed in cases where a patient is experiencing infrequent bowel movements that may persist for about 3 months or a longer period of time without necessarily being resultant of certain medications or diseases. The drug may also be used to relieve constipation that may result from specific opioid (narcotic) use amongst people who have persistent pain that is not caused by cancer. Lubiprostone is classified as a laxative and its mechanism of action entails enhancing the flow of fluid into the bowel for easier bowel movements.

Marketed under the trade name Amitiza, Lubiprostone is a chloride channel activator which is mainly used for the treatment of idiopathic (due to an unknown cause) chronic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. Lubiprostone is an oral medication approved by the FDA in January 2006.
The mechanism of action of lubiprostone is the same as chloride channel activator. It functions by binding and activating ClC-2 chloride channels in the apical membrane of the gastrointestinal epithelium, which produces an efflux of chloride-rich fluid secretion. The increased amounts of secretions are effective to soften the stool, increase motility, promote spontaneous bowel movements (SBM), and speed up transit of stool in the colon. Therefore, the relevant symptoms, such as abdominal pain and bloating, can be reduced.

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Lubiprostone (SPI-0211) is a fatty acid metabolite analog of prostaglandin E1. It has been reported that lubiprostone is a locally acting type II chloride channel (ClC-2) activator in the small intestinal epithelial cells, and enhances a chloride-rich intestinal fluid secretion without altering sodium and potassium concentrations in the serum. By increasing intestinal fluid secretion, lubiprostone increases motility in the intestine, thereby facilitating the passage of stool and alleviating symptoms associated with chronic idiopathic constipation. (The product is for research purpose only.)

Catalogue Number L473500
Chemical Name Lubiprostone
Synonyms (11α)-16,16-Difluoro-11-hydroxy-9,15-dioxo-prostan-1-oic Acid; Ru 0211;
CAS Number 136790-76-6
Molecular Formula C??H??F?O?
Appearance White to Off-White Solid
Melting Point 56 - 60°C
Molecular Weight 390.46
Storage -20°C Freezer
Solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Category Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1. It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, increase gastrointestinal transit, and improve symptoms of constipation.

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