High purity DelaManid in China cost

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0 Metric Ton	Negotiable

0 Metric Ton

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Min.Order :0 Metric Ton
Purity: 98
Payment Terms : L/C,T/T

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High purity DelaManid DelaManid cost DelaManid in China

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High purity DelaManid in China cost

Delamanid is used for the treatment of multi-drug-resistant tuberculosis. It functions by blocking the synthesis of mycolic acids in Mycobacterium tuberculosis, the organism which causes tuberculosis, thus destabilising its cell wall.

Delamanid is an antimycobacterial compound. It is active against clinical isolates of M. tuberculosis that are susceptible (MIC₉₀s = 0.01194-0.01248 μg/ml) or resistant to rifampicin (Item No. 14423), isoniazid (Item No. 20378), ethambutol (Item No. 23713), and/or streptomycin (Item No. 21211; MIC₉₀s = 0.01221-0.01341 μg/ml). It inhibits the synthesis of methoxy- and keto-mycolic acid in the M. bovis strain BCG (IC₅₀s = 0.036 and 0.021 μg/ml, respectively). Delamanid (0.1, 0.3, and 1 μg/ml) inhibits the growth of the M. tuberculosis strain H37Rv in infected THP-1 cells. It decreases lung bacterial burden in a mouse model of M. tuberculosis infection in a dose-dependent manner.

Delamanid is a new antituberculosis drug that inhibits mycolic acid synthesis and has shown potent in vitro and in vivo activity against drug-resistant strains of Mycobacterium tuberculosis.

Details:

Formal Name

(2R)-2,3-dihydro-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl]phenoxy]methyl]-imidazo[2,1-b]oxazole

CAS Number

681492-22-8

Synonyms

OPC-67683

Molecular Formula

C₂₅H₂₅F₃N₄O₆

Formula Weight

534.5

Purity

≥98%

Formulation

A crystalline solid

Solubility(Learn about Variance in Solubility)

DMF: 25 mg/ml
DMSO: 20 mg/ml
Ethanol: partially soluble

λ_max

220, 244, 316 nm

SMILES

FC(F)(F)OC(C=C1)=CC=C1OC2CCN(C3=CC=C(OC[C@]4(C)OC5=NC([N+]([O-])=O)=CN5C4)C=C3)CC2

InChi Code

InChI=1S/C25H25F3N4O6/c1-24(15-31-14-22(32(33)34)29-23(31)38-24)16-35-18-4-2-17(3-5-18)30-12-10-20(11-13-30)36-19-6-8-21(9-7-19)37-25(26,27)28/h2-9,14,20H,10-13,15-16H2,1H3/t24-/m1/s1

InChi Key

XDAOLTSRNUSPPH-XMMPIXPASA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 2 years

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