Min.Order / FOB Price:Get Latest Price
0 Metric Ton |
Negotiable |
Supply 6-Ethylchenodeoxycholic acid(Obeticholic Acid) lowest price 6-Ethylchenodeoxycholic acid(Obeticholic Acid) 6-Ethylchenodeoxycholic acid(Obeticholic Acid) manufacturer
Supply lowest price 6-Ethylchenodeoxycholic acid(Obeticholic Acid) manufacturer
Obeticholic acid is a semi-synthetic bile acid analogue and acts as a farnesoid-X receptor (FXR) agonist. It is used for the treatment of primary biliary cholangitis. It is also under investigation for the treatment of other liver diseases,primary biliary cirrhosis, bile acid diarrhea and related disorders. Study has shown that it also has potential for treating nonalcoholicsteatohepatitis (NASH), and portal hypertension. Obeticholic acid takes effect through acting s the agonist of the farnesoid X receptor (FXR), which is the regulator of bile and cholesterol metabolism in the liver.
Obeticholic acid is also called 6-Ethylchenodeoxycholic acid. It is a new derivative of chenodeoxycholic acid (CDCA) in human primary bile acids, a natural ligand for farnesoid x receptors (FXR). Obeticholic acid was developed by American pharmaceutical company Intercept as the first drug to treat cholestatic liver disease in 20 years, and it is administered on patients that do not respond well to or cannot tolerate the old standard treatment drug ursodeoxycholic acid. Obeticholic acid has also been tested to treat a more common form of fatty liver – non-alcoholic fatty liver disease (NAFLD). Obeticholic acid can also be developed to treat other liver and intestine diseases.
Farnesoid X receptor (FXR) is a nuclear receptor that is activated by bile acid, with chenodeoxycholic acid (CDCA) being a representative natural ligand. 6-
Catalogue Number | E899810 |
Chemical Name | 6-Ethylchenodeoxycholic Acid |
Synonyms | (3α,5β,6α,7α)-6-Ethyl-3,7-dihydroxycholan-24-oic Acid; 3α,7β-Dihydroxy-6α-ethyl-5β-cholan-24-oic Acid; 6-ECDCA; 6α-Ethylchenodeoxycholic Acid; INT 747; Obeticholic Acid; Ocaliva; |
CAS Number | 459789-99-2 |
Molecular Formula | C??H??O? |
Appearance | White to Off-White Solid |
Melting Point | >98ºC (dec.) |
Molecular Weight | 420.63 |
Storage | -20°C Freezer |
Solubility | Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly) |
Category | Standards; Steroids; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
Applications | 6-Ethylchenodeoxycholic Acid is a derivative of the bile acid Chenodeoxycholic Acid (C291900). 6-Ethylchenodeoxycholic Acid is a potent activator of the farnesoid X nuclear receptor which reduces liver fat and fibrosis in animal models of fatty liver disease. |
CAS NO:18704-37-5
CAS NO:91421-43-1
CAS NO:182182-31-6
CAS NO:110351-94-5
CAS NO:200636-54-0
CAS NO:144848-24-8
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View