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Purity: 99%
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Supply Everolimus in Stock fast delivery

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that, as part of two distinct complexes (mTORC1 and mTORC2), plays pivotal roles in intracellular signaling. Everolimus is a hydroxyethyl ether rapamycin (Item No. 13346) derivative that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM. It is orally available and shows improved pharmacokinetics and pharmacodynamics over rapamycin. Through its inhibition of mTOR, everolimus inhibits cell proliferation, metabolism, and angiogenesis in certain types of cancer. It also acts as an immunosuppressive agent in the context of organ transplantation

Everolimus is a mTOR inhibitor. Inhibits tumor proliferation in vitro and in vivo. Inhibits VEGF-induced HUVEC proliferation in vitro, but does not affect tumor vascular permeability in mouse models. Immunosuppressant. Activates autophagy.

Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cytokine-mediated lymphocyte proliferation. Everolimus can be used as an immunosuppressant in the treatment of renal cell cancer and other cancers.

Details:

Catalogue Number	E945400
Chemical Name	Everolimus (~90% pure)
Synonyms	40-O-(2-Hydroxyethyl)rapamycin; 42-O-(2-Hydroxy)ethyl Rapamycin; Afinitor; Certican; RAD; RAD 001; SDZ-RAD; XIENCE V;
Impurity	Everolimus EP Impurity C
CAS Number	159351-69-6
Molecular Formula	C??H??NO??
Appearance	White to Light Beige Solid
Melting Point	100 - 104ºC
Molecular Weight	958.24
Storage	Hygroscopic, -20°C Freezer, Under Inert atmosphere
Solubility	Chloroform (Slightly), Methanol (Slightly, Sonicated)
Stability	Hygroscopic
Category	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications	Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.