High purity Fasudil with best price and good quality

Product Name:

FASUDIL

Synonyms:

FASUDIL;1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE;at877;hexahydro-1-(5-isoquinolinylsulfonyl)-1h-4-diazepine;HA-1077 DIHYDROCHLORIDE NOVEL VASODILATO R AGE;HA 1077, DIHYDROCHLORIDE, 99+%;Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine;HA-1077：Eril

CAS:

103745-39-7

MF:

C14H17N3O2S

MW:

291.37

Product Categories:

Protein Kinase Inhibitors and Activators;Protein Kinase;Signalling;Angiogenesis and Metastasis;Intracellular signaling;APIs;ERIL

Mol File:

103745-39-7.mol

Chemical Properties

boiling point 

506.2 °C at 760 mmHg

density 

1.289 g/cm3

vapor pressure 

2.27E-10 mmHg at 25 °C

flashing point 

259.9 °C

storage temp. 

Store at RT

solubility 

H2O: >200 mg/mL

Usage And Synthesis

Chemical Properties

White Crystalline Solid

Usage

vasodilator (cerebral), Ca antagonist

A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced co ntraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho- associated Kinase (ROCK IC50= 10.7 uM).

Biological Activity

Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells.