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Prednisolone Acetate 52-21-1 (11beta)-21-(Acetyloxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione;11,17-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate;11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate;21-(acetyloxy)-
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Prednisolone-21-acetate
1. CAS No.: 52-21-1
2. Quality: USP35
3. Specification of Prednisolone-21-acetate
Items | Specifications | Results |
Character | White or almost white crystallin powder | Almost white crystalline powder |
Specific rotation | +112°~+119° | +118.3° |
Identification | 1) Complies by IR | Conforms |
2) Complies by UV not more than 2.5% | 1.20% | |
3) Positive reaction | Conforms | |
Chromatographic purity | Principal impurity not more than 1.0% | 0.32% |
Total impurities not more than 2.0% | 0.69% | |
Methanol | ≤3000ppm | 438ppm |
Pyridine | ≤200ppm | 31ppm |
Loos on drying | Not more than 1.0% | 0.10% |
Assay | Contains 97.0% to 102.0% of C23H306 calculated on dried basis | 100.40% |
Conclusion | The results can conforms with USP35 |
4. Usage of Prednisolone-21-acetate
1) Prednisolone acetate ophthalimic suspension (eye drops) is an adrenocortical steroid product, prepared as a sterile
opthalmic suspension and used to reduce swellig, redness, itching, and allergic reactions affecting the eye.
2) Prednisolone acetate is used as an antiallergic and immunosuppressive drug and as an anti-inflammatory agent in
the treatment of rheumatoid arthritis
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