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Triamcinolone Acetonide Acetate
1. CAS No.: 76-25-5
2. Quality: EP5/USP34
3. Specification of Triamcinolone Acetonide Acetate
EP5
Items | Specifications | Results |
Characters | A white or almost white crystalline powder | Almost white crystalline powder |
Identification | A: IR Absorption | Complies |
B:TLC | Complies | |
Specific optical rotation | Between +100°and +107° | +102° |
Water | Not more than 2.0% | 1.30% |
Related substances | Any infividual impurity not more than 0.25% | 0.18% |
Total impurities not more than 0.5% | 0.30% | |
Assay | Between 97.0%~103.0% | 100.60% |
Particle size | ||
100%<15μm | 100%<15μm | |
99%<10μm | 99.0%<10μm | |
80%<5μm | 80.0%<5μm | |
Conclusion | The results can conform with EP5 |
USP34
Items | Specifications | Results |
Appearance | White or almost white crystalline powder | White crystalline powder |
Identification | 1) Infrared Absorption | Compliance |
2) Ultraviolet Absorption | ||
Specific Rotation | +118°~+130° | +121° |
Loss on drying | ≤1.5% | 0.10% |
Heavy metals | ≤0.0025% | Compliance |
Chromatographic Purity | Any individual impurity ≤0.3% | Any dividual impurity: 0.08% |
Total impurities≤0.8% | Total impurities: 0.4% | |
Residual solvent | Methanol≤0.3% | 0.03% |
Ethanol≤0.5% | 0.04% | |
Acetone≤0.5% | Not detected | |
Chloroform≤0.006% | 0.00% | |
Assay | 97.0%~102.0%, calculated on the dried basis | 100.60% |
Particle Size | D90=28.15μm | |
Conclusion | The product conforms to USP34 |
4. Usage of Triamcinolone Acetonide Acetate
1) Triamcinolone Acetonide is used to treat various skin conditions, relieve the discomfort of mouth sores,
and nasal spray form, to treat allergic rhinitis
2) Triamcinolone acetonide has been used in various eye diseases and has been found useful in reducing
macular edema
3) Triamcinolone Acetonide is also used in veterinary medicine as an ingredient in topical ointments, also
in topical sprays for control of pruritus in dogs
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