Noradrenaline Bitartrate 69815-49-2 (-)-(R)-NOREPINEPHRINE HYDROGEN TARTRATE MONOHYDRATE;(-)-arterenolbitartratehydrate;L-(-)-NOREPINEPHRINE (+)-BITARTRATE SALT MONOHYDRATE;L-NOREPINEPHRINE BITARTRATE, MONOHYDRATE;L-NORADRENALINE HYDROG
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1. The Specification of Noradrenaline Bitartrate
Items | Specifications | Results |
Appearance | White to faintly gray, odorless, crystalline powder | Conforms |
Solubility | Freely soluble in water, slightly soluble in ethanol (96%) | Conforms |
Identification | ||
A: | Infrared absorption | Conforms |
B: | An intensely green color develops | Conforms |
C: | The solution is colorless or has at most a slight pink or slight violet color | Conforms |
Specific rotation | Between -10°and -12° | -11.4° |
Water | Between 4.5% and 5.8% | 5.40% |
Residue on ignition | Not more than 0.1%, from 200mg | 0.03% |
Limit of arterenone | Not more than 0.2 | 0 |
Assay | 97.0~102.0%, calculated on the anhydrous basis | 99.30% |
Further Test | ||
Bacterial endotoxins | Not more than 83.4EU/mg of Noradrenaline base | <83.4 EU/mg |
Residual Solvent | Ethanol content: Not more than 5000ppm | 28ppm |
Conclusion | It conforms to USP36. |
2. The usage of Noradrenaline Bitartrate
As adrenergic receptor, the contraction of blood vessels and boost the role of strong and heart rate caused by
reflex, but sitmulate the heart, bronchodilators are less effective, Mainly used in anti-shock, as a result of
anesthesia induced shock, toxic shock, cardiac shock .
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