Hot sale ! AICAR/2627-69-2/99% high purity in stock CAS NO.2627-69-2
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| 1 Kilogram |
Negotiable |
- Min.Order :1 Kilogram
- Purity: 99.0%
- Payment Terms : L/C,D/A,D/P,T/T,Other
Keywords
supplier of AICAR（Acadesine） buy 2627-69-2 AICAR（Acadesine）with best price Offer 2627-69-2 AICAR（Acadesine） CAS NO.2627-69-2
Quick Details
- Appearance:white crystalline powder
- Application:1>2627-69-2 2>AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating age
- PackAge:1g;5g;10g;25g;50g;100g;500g;1KG;5KG,25kg,50kg Aluminum foil bag fluoride bottle or as customers request
- ProductionCapacity:100|Kilogram|Quarter
- Storage:2-8, cold storage, to avoid light storage.
- Transportation:BY SEA /BY AIR /BY COURIER
Superiority:
1.High purity with HPLC & NMR chart;
2.99% purity with low price;
3.Direct manufacturer;
4.specilized in hard-to-find chemicals.
| CBNumber: | CB1675294 |
| Chemical Name: | AICAR |
Details:
| CBNumber: | CB1675294 |
| Chemical Name: | AICAR |
|
AICAR Basic information |
| adenosine regulating agents |
| Product Name: | AICAR |
| Synonyms: | ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE |
| CAS: | 2627-69-2 |
| MF: | C9H14N4O5 |
| MW: | 258.23 |
| EINECS: | 220-097-5 |
| Product Categories: | Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;ARASINE;Cardiovascular APIs;PI3K/Akt/mTOR |
| Mol File: | 2627-69-2.mol |
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| AICAR Chemical Properties |
| mp | 214-215 °C |
| storage temp. | −20°C |
| solubility | H2O: >10 mg/mL |
| form | powder |
| color | tan |
| CAS DataBase Reference | 2627-69-2(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2) |
| Safety Information |
| Hazard Codes | Xi,T |
| Risk Statements | 36/37/38-61 |
| Safety Statements | 26-36-45-53 |
| WGK Germany | 3 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| AICAR Usage And Synthesis |
| adenosine regulating agents |
Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate). Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death. |
| Chemical Properties | Solid |
| Usage | glucose uptake stimulant; AMPK activator |
| Usage | AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective. |
| Biological Activity | Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. |
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